A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016
Hepatitis E is an emerging viral disease that is the leading cause of viral hepatitis in the world. The vast majority of hepatitis E cases in developed countries are caused by zoonotic genotypes 3 and 4 of hepatitis E virus (HEV) for which pig and wild boar and to lesser extent rabbits are the main...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1065 |
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| author | Filip Cierniak Felicitas von Arnim Gerald Heckel Rainer G. Ulrich Martin H. Groschup Martin Eiden |
| author_facet | Filip Cierniak Felicitas von Arnim Gerald Heckel Rainer G. Ulrich Martin H. Groschup Martin Eiden |
| author_sort | Filip Cierniak |
| collection | DOAJ |
| description | Hepatitis E is an emerging viral disease that is the leading cause of viral hepatitis in the world. The vast majority of hepatitis E cases in developed countries are caused by zoonotic genotypes 3 and 4 of hepatitis E virus (HEV) for which pig and wild boar and to lesser extent rabbits are the main reservoir. According to recent reports rabbits are a source of human HEV infection and highlight the risk of zoonotic foodborne transmission. Here we report the molecular analysis of a novel HEV strain identified in a rabbit during a countrywide surveillance of rabbits and hares in Germany, 2016. The analysis of the complete genome reveals characteristics of a putative novel recombinant subtype of the species <i>Orthohepevirus A</i> within the clade of genotype 3 but not closely related to any known subtypes. Importantly, the genome of this strain possesses a nucleotide exchange in the overlapping region of open reading frames ORF2/ORF3 interfering with a broadly applied diagnostic real-time RT-PCR. In conclusion, a new type of HEV strain was identified in a German rabbit with atypical and novel sequence characteristics. |
| first_indexed | 2024-03-10T10:43:49Z |
| format | Article |
| id | doaj.art-428e2a0e76b143c8ad383a50eb7e48d7 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:43:49Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-428e2a0e76b143c8ad383a50eb7e48d72023-11-21T22:43:41ZengMDPI AGViruses1999-49152021-06-01136106510.3390/v13061065A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016Filip Cierniak0Felicitas von Arnim1Gerald Heckel2Rainer G. Ulrich3Martin H. Groschup4Martin Eiden5Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, GermanyInstitute of Ecology and Evolution, University of Bern, 3012 Bern, SwitzerlandInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, GermanyInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, GermanyHepatitis E is an emerging viral disease that is the leading cause of viral hepatitis in the world. The vast majority of hepatitis E cases in developed countries are caused by zoonotic genotypes 3 and 4 of hepatitis E virus (HEV) for which pig and wild boar and to lesser extent rabbits are the main reservoir. According to recent reports rabbits are a source of human HEV infection and highlight the risk of zoonotic foodborne transmission. Here we report the molecular analysis of a novel HEV strain identified in a rabbit during a countrywide surveillance of rabbits and hares in Germany, 2016. The analysis of the complete genome reveals characteristics of a putative novel recombinant subtype of the species <i>Orthohepevirus A</i> within the clade of genotype 3 but not closely related to any known subtypes. Importantly, the genome of this strain possesses a nucleotide exchange in the overlapping region of open reading frames ORF2/ORF3 interfering with a broadly applied diagnostic real-time RT-PCR. In conclusion, a new type of HEV strain was identified in a German rabbit with atypical and novel sequence characteristics.https://www.mdpi.com/1999-4915/13/6/1065hepatitis E virusnovel genotyperabbit |
| spellingShingle | Filip Cierniak Felicitas von Arnim Gerald Heckel Rainer G. Ulrich Martin H. Groschup Martin Eiden A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016 Viruses hepatitis E virus novel genotype rabbit |
| title | A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016 |
| title_full | A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016 |
| title_fullStr | A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016 |
| title_full_unstemmed | A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016 |
| title_short | A Putative Novel Hepatitis E Virus Genotype 3 Subtype Identified in Rabbit, Germany 2016 |
| title_sort | putative novel hepatitis e virus genotype 3 subtype identified in rabbit germany 2016 |
| topic | hepatitis E virus novel genotype rabbit |
| url | https://www.mdpi.com/1999-4915/13/6/1065 |
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