| Summary: | The increase of morbidity and invalidization frequency of patients with the breast cancer stipulates a necessity to find of the new diagnostic ways and prognostic markers with the aim for early diagnostic, optimization and individual way of therapy that will allow to improve the quality of life, patients’ physical and social reabilitation. The purpose of our investigation was to estimate an expression of important biological markers of tumor’s bihavior – p53 and Ki-67 (proliferative markers) at women suffering from breast cancer of different age by immunohistochemical method. We have examined 300 women with 5 markers (estrogen and progesteron receptors - ER, PgR; human epidermal growth factor receptor HER-2/neu; p53-oncoprotein, presenolin pS2), and 150 women with 7 markers (additionally Ki-67, bcl-2). Our data suggests that the proliferative activity of breast cancer cells is higher at patients with metastasis. Besides, we have estimated correlation between young age of women and p53-pozitive status. Thus, it allows their using as independent prognostic markers which are evidence of high metastatic and invasive tumor potential.
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