The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancer
The increase of morbidity and invalidization frequency of patients with the breast cancer stipulates a necessity to find of the new diagnostic ways and prognostic markers with the aim for early diagnostic, optimization and individual way of therapy that will allow to improve the quality of life, pat...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2007-01-01
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| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2007-01-01/07bvaomj.pdf |
| _version_ | 1818420993232732160 |
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| author | Bondareva V.A. Shponka I.S. |
| author_facet | Bondareva V.A. Shponka I.S. |
| author_sort | Bondareva V.A. |
| collection | DOAJ |
| description | The increase of morbidity and invalidization frequency of patients with the breast cancer stipulates a necessity to find of the new diagnostic ways and prognostic markers with the aim for early diagnostic, optimization and individual way of therapy that will allow to improve the quality of life, patients’ physical and social reabilitation. The purpose of our investigation was to estimate an expression of important biological markers of tumor’s bihavior – p53 and Ki-67 (proliferative markers) at women suffering from breast cancer of different age by immunohistochemical method. We have examined 300 women with 5 markers (estrogen and progesteron receptors - ER, PgR; human epidermal growth factor receptor HER-2/neu; p53-oncoprotein, presenolin pS2), and 150 women with 7 markers (additionally Ki-67, bcl-2). Our data suggests that the proliferative activity of breast cancer cells is higher at patients with metastasis. Besides, we have estimated correlation between young age of women and p53-pozitive status. Thus, it allows their using as independent prognostic markers which are evidence of high metastatic and invasive tumor potential. |
| first_indexed | 2024-12-14T13:03:17Z |
| format | Article |
| id | doaj.art-428ebfcf2fac4ec1a5db11f2013186fb |
| institution | Directory Open Access Journal |
| issn | 1997-9665 |
| language | Russian |
| last_indexed | 2024-12-14T13:03:17Z |
| publishDate | 2007-01-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-428ebfcf2fac4ec1a5db11f2013186fb2022-12-21T23:00:23ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96652007-01-01114044The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancerBondareva V.A.Shponka I.S.The increase of morbidity and invalidization frequency of patients with the breast cancer stipulates a necessity to find of the new diagnostic ways and prognostic markers with the aim for early diagnostic, optimization and individual way of therapy that will allow to improve the quality of life, patients’ physical and social reabilitation. The purpose of our investigation was to estimate an expression of important biological markers of tumor’s bihavior – p53 and Ki-67 (proliferative markers) at women suffering from breast cancer of different age by immunohistochemical method. We have examined 300 women with 5 markers (estrogen and progesteron receptors - ER, PgR; human epidermal growth factor receptor HER-2/neu; p53-oncoprotein, presenolin pS2), and 150 women with 7 markers (additionally Ki-67, bcl-2). Our data suggests that the proliferative activity of breast cancer cells is higher at patients with metastasis. Besides, we have estimated correlation between young age of women and p53-pozitive status. Thus, it allows their using as independent prognostic markers which are evidence of high metastatic and invasive tumor potential.http://www.morphology.dp.ua/_pub/MORPHO-2007-01-01/07bvaomj.pdfproliferative potentialprognostic markersimmunohistochemical methodsbiological properties of tumoroncoproteins |
| spellingShingle | Bondareva V.A. Shponka I.S. The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancer Морфологія proliferative potential prognostic markers immunohistochemical methods biological properties of tumor oncoproteins |
| title | The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancer |
| title_full | The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancer |
| title_fullStr | The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancer |
| title_full_unstemmed | The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancer |
| title_short | The importance of prognostic markers of tumor progression Ki-67 and р53 in the breast cancer |
| title_sort | importance of prognostic markers of tumor progression ki 67 and р53 in the breast cancer |
| topic | proliferative potential prognostic markers immunohistochemical methods biological properties of tumor oncoproteins |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2007-01-01/07bvaomj.pdf |
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