Role of Nucleoporins and Transport Receptors in Cell Differentiation
Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane. These macromolecular structures are composed of several nucleoporins, which form seven different subcomplexes based on their biochemical affinity. Th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00239/full |
| _version_ | 1819158648481382400 |
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| author | Asmat Ullah Khan Rongmei Qu Jun Ouyang Jingxing Dai |
| author_facet | Asmat Ullah Khan Rongmei Qu Jun Ouyang Jingxing Dai |
| author_sort | Asmat Ullah Khan |
| collection | DOAJ |
| description | Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane. These macromolecular structures are composed of several nucleoporins, which form seven different subcomplexes based on their biochemical affinity. These nucleoporins are integral components of the complex, not only allowing passive transport but also interacting with importin, exportin, and other molecules that are required for transport of protein in various cellular processes. Transport of different proteins is carried out either dependently or independently on transport receptors. As well as facilitating nucleocytoplasmic transport, nucleoporins also play an important role in cell differentiation, possibly by their direct gene interaction. This review will cover the general role of nucleoporins (whether its dependent or independent) and nucleocytoplasmic transport receptors in cell differentiation. |
| first_indexed | 2024-12-22T16:28:00Z |
| format | Article |
| id | doaj.art-428edfd6c0c54aaeb7ecf9abce4321fd |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T16:28:00Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-428edfd6c0c54aaeb7ecf9abce4321fd2022-12-21T18:20:07ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-04-011110.3389/fphys.2020.00239515523Role of Nucleoporins and Transport Receptors in Cell DifferentiationAsmat Ullah KhanRongmei QuJun OuyangJingxing DaiBidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane. These macromolecular structures are composed of several nucleoporins, which form seven different subcomplexes based on their biochemical affinity. These nucleoporins are integral components of the complex, not only allowing passive transport but also interacting with importin, exportin, and other molecules that are required for transport of protein in various cellular processes. Transport of different proteins is carried out either dependently or independently on transport receptors. As well as facilitating nucleocytoplasmic transport, nucleoporins also play an important role in cell differentiation, possibly by their direct gene interaction. This review will cover the general role of nucleoporins (whether its dependent or independent) and nucleocytoplasmic transport receptors in cell differentiation.https://www.frontiersin.org/article/10.3389/fphys.2020.00239/fullnuclear pore complexes (NPCs)differentiationnucleoporinnucleocytoplasmic transportnuclear membrane |
| spellingShingle | Asmat Ullah Khan Rongmei Qu Jun Ouyang Jingxing Dai Role of Nucleoporins and Transport Receptors in Cell Differentiation Frontiers in Physiology nuclear pore complexes (NPCs) differentiation nucleoporin nucleocytoplasmic transport nuclear membrane |
| title | Role of Nucleoporins and Transport Receptors in Cell Differentiation |
| title_full | Role of Nucleoporins and Transport Receptors in Cell Differentiation |
| title_fullStr | Role of Nucleoporins and Transport Receptors in Cell Differentiation |
| title_full_unstemmed | Role of Nucleoporins and Transport Receptors in Cell Differentiation |
| title_short | Role of Nucleoporins and Transport Receptors in Cell Differentiation |
| title_sort | role of nucleoporins and transport receptors in cell differentiation |
| topic | nuclear pore complexes (NPCs) differentiation nucleoporin nucleocytoplasmic transport nuclear membrane |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00239/full |
| work_keys_str_mv | AT asmatullahkhan roleofnucleoporinsandtransportreceptorsincelldifferentiation AT rongmeiqu roleofnucleoporinsandtransportreceptorsincelldifferentiation AT junouyang roleofnucleoporinsandtransportreceptorsincelldifferentiation AT jingxingdai roleofnucleoporinsandtransportreceptorsincelldifferentiation |