Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration
The three-dimensional (3D) cell-printing technique has been identified as a new biofabrication platform because of its ability to locate living cells in pre-defined spatial locations with scaffolds and various growth factors. Osseointegrated dental implants have been regarded as very reliable and ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1337 |
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| author | Ui-Lyong Lee Seokhwan Yun Hua-Lian Cao Geunseon Ahn Jin-Hyung Shim Su-Heon Woo Pill-Hoon Choung |
| author_facet | Ui-Lyong Lee Seokhwan Yun Hua-Lian Cao Geunseon Ahn Jin-Hyung Shim Su-Heon Woo Pill-Hoon Choung |
| author_sort | Ui-Lyong Lee |
| collection | DOAJ |
| description | The three-dimensional (3D) cell-printing technique has been identified as a new biofabrication platform because of its ability to locate living cells in pre-defined spatial locations with scaffolds and various growth factors. Osseointegrated dental implants have been regarded as very reliable and have long-term reliability. However, host defense mechanisms against infections and micro-movements have been known to be impaired around a dental implant because of the lack of a periodontal ligament. In this study, we fabricated a hybrid artificial organ with a periodontal ligament on the surface of titanium using 3D printing technology. CEMP-1, a known cementogenic factor, was enhanced in vitro. In animal experiments, when the hybrid artificial organ was transplanted to the calvarial defect model, it was observed that the amount of connective tissue increased. 3D-printed hybrid artificial organs can be used with dental implants, establishing physiological tooth functions, including the ability to react to mechanical stimuli and the ability to resist infections. |
| first_indexed | 2024-03-10T10:56:26Z |
| format | Article |
| id | doaj.art-428ee38024154e08a9e65285bab670f9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:56:26Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-428ee38024154e08a9e65285bab670f92023-11-21T21:48:11ZengMDPI AGCells2073-44092021-05-01106133710.3390/cells10061337Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament RegenerationUi-Lyong Lee0Seokhwan Yun1Hua-Lian Cao2Geunseon Ahn3Jin-Hyung Shim4Su-Heon Woo5Pill-Hoon Choung6Department of Oral & Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, KoreaDepartment of Mechanical Engineering, Korea Polytechnic University, Siheung-si 15073, Gyoenggi, KoreaDepartment of Oral & Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, KoreaResearch Institute, T&R Biofab Co., Ltd., Siheung-si 15073, Gyoenggi, KoreaDepartment of Mechanical Engineering, Korea Polytechnic University, Siheung-si 15073, Gyoenggi, KoreaR & D Center, Medyssey Co., Ltd., Jechon-si 27159, Gyeongsanbuk, KoreaDepartment of Oral & Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, KoreaThe three-dimensional (3D) cell-printing technique has been identified as a new biofabrication platform because of its ability to locate living cells in pre-defined spatial locations with scaffolds and various growth factors. Osseointegrated dental implants have been regarded as very reliable and have long-term reliability. However, host defense mechanisms against infections and micro-movements have been known to be impaired around a dental implant because of the lack of a periodontal ligament. In this study, we fabricated a hybrid artificial organ with a periodontal ligament on the surface of titanium using 3D printing technology. CEMP-1, a known cementogenic factor, was enhanced in vitro. In animal experiments, when the hybrid artificial organ was transplanted to the calvarial defect model, it was observed that the amount of connective tissue increased. 3D-printed hybrid artificial organs can be used with dental implants, establishing physiological tooth functions, including the ability to react to mechanical stimuli and the ability to resist infections.https://www.mdpi.com/2073-4409/10/6/13373D printingdental implantperiodontal ligamentstem cellscaffold |
| spellingShingle | Ui-Lyong Lee Seokhwan Yun Hua-Lian Cao Geunseon Ahn Jin-Hyung Shim Su-Heon Woo Pill-Hoon Choung Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration Cells 3D printing dental implant periodontal ligament stem cell scaffold |
| title | Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration |
| title_full | Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration |
| title_fullStr | Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration |
| title_full_unstemmed | Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration |
| title_short | Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration |
| title_sort | bioprinting on 3d printed titanium scaffolds for periodontal ligament regeneration |
| topic | 3D printing dental implant periodontal ligament stem cell scaffold |
| url | https://www.mdpi.com/2073-4409/10/6/1337 |
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