Co-expression and interaction network analysis reveals dysregulated neutrophil and T-cell activation as the core mechanism associated with septic shock

Co-expression and interaction network analysis reveals dysregulated neutrophil and T-cell activation as the core mechanism associated with septic shock

Septic shock as a subset of sepsis, has a much higher mortality, while the mechanism is still elusive. This study was aimed at identifying core mechanisms associated with septic shock and its high mortality by investigating transcriptome data. We screened 72 septic-shock-associated genes (SSAGs) wit...

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Bibliographic Details
Main Authors: Shaobo Zhao, Kun Zhu, Xiaoyi Li, Xiaohui Zhong, Yanan Zhao, Zhenkai Le, Zhicong Liu, Yi Xiao, Dengming Lai, Na Jiao, Qiang Shu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Genetics
Subjects:
bioinformatics
neutrophil
ELANE
T cell
septic shock
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1132361/full

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