Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound
Ultrasound with low frequency (20–100 kHz) assisted drug delivery has been widely investigated as a non-invasive method to enhance the permeability and retention effect of drugs. The functional micro/nanobubble loaded with drugs could provide an unprecedented opportunity for targeted delivery. Then,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/3/480 |
| _version_ | 1797443618043068416 |
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| author | Shirui Lu Pengxuan Zhao Youbin Deng Yani Liu |
| author_facet | Shirui Lu Pengxuan Zhao Youbin Deng Yani Liu |
| author_sort | Shirui Lu |
| collection | DOAJ |
| description | Ultrasound with low frequency (20–100 kHz) assisted drug delivery has been widely investigated as a non-invasive method to enhance the permeability and retention effect of drugs. The functional micro/nanobubble loaded with drugs could provide an unprecedented opportunity for targeted delivery. Then, ultrasound with higher intensity would locally burst bubbles and release agents, thus avoiding side effects associated with systemic administration. Furthermore, ultrasound-mediated destruction of micro/nanobubbles can effectively increase the permeability of vascular membranes and cell membranes, thereby not only increasing the distribution concentration of drugs in the interstitial space of target tissues but also promoting the penetration of drugs through cell membranes into the cytoplasm. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theragnostic tool. In this review, we first discuss the structure and generation of micro/nanobubbles. Second, ultrasound parameters and mechanisms of therapeutic delivery are discussed. Third, potential biomedical applications of micro/nanobubble-assisted ultrasound are summarized. Finally, we discuss the challenges and future directions of ultrasound combined with micro/nanobubbles. |
| first_indexed | 2024-03-09T12:59:38Z |
| format | Article |
| id | doaj.art-428f47329b9d46a8acc27864fadc2cb3 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:59:38Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-428f47329b9d46a8acc27864fadc2cb32023-11-30T21:55:30ZengMDPI AGPharmaceutics1999-49232022-02-0114348010.3390/pharmaceutics14030480Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted UltrasoundShirui Lu0Pengxuan Zhao1Youbin Deng2Yani Liu3Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaUltrasound with low frequency (20–100 kHz) assisted drug delivery has been widely investigated as a non-invasive method to enhance the permeability and retention effect of drugs. The functional micro/nanobubble loaded with drugs could provide an unprecedented opportunity for targeted delivery. Then, ultrasound with higher intensity would locally burst bubbles and release agents, thus avoiding side effects associated with systemic administration. Furthermore, ultrasound-mediated destruction of micro/nanobubbles can effectively increase the permeability of vascular membranes and cell membranes, thereby not only increasing the distribution concentration of drugs in the interstitial space of target tissues but also promoting the penetration of drugs through cell membranes into the cytoplasm. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theragnostic tool. In this review, we first discuss the structure and generation of micro/nanobubbles. Second, ultrasound parameters and mechanisms of therapeutic delivery are discussed. Third, potential biomedical applications of micro/nanobubble-assisted ultrasound are summarized. Finally, we discuss the challenges and future directions of ultrasound combined with micro/nanobubbles.https://www.mdpi.com/1999-4923/14/3/480ultrasoundmicro/nanobubblesdrug deliverymembrane permeability |
| spellingShingle | Shirui Lu Pengxuan Zhao Youbin Deng Yani Liu Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound Pharmaceutics ultrasound micro/nanobubbles drug delivery membrane permeability |
| title | Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound |
| title_full | Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound |
| title_fullStr | Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound |
| title_full_unstemmed | Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound |
| title_short | Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound |
| title_sort | mechanistic insights and therapeutic delivery through micro nanobubble assisted ultrasound |
| topic | ultrasound micro/nanobubbles drug delivery membrane permeability |
| url | https://www.mdpi.com/1999-4923/14/3/480 |
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