Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity.
Cefotaxime (HR 756) was compared with cefazolin and cephaloridine with regard to the rate of bacterial killing and to the influence on the bactericidal activity of human serum and polyrnorphonuclear leukocytes. At concentrations equal to 1-2 x MIC cefotaxime showed a more rapid and complete bacteri...
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
1983-03-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790 |
| _version_ | 1811344742339837952 |
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| author | Giuliana Gialdroni Grassi Patrizia Mangiarotti Anna Fietta |
| author_facet | Giuliana Gialdroni Grassi Patrizia Mangiarotti Anna Fietta |
| author_sort | Giuliana Gialdroni Grassi |
| collection | DOAJ |
| description |
Cefotaxime (HR 756) was compared with cefazolin and cephaloridine with regard to the rate of bacterial killing and to the influence on the bactericidal activity of human serum and polyrnorphonuclear leukocytes. At concentrations equal to 1-2 x MIC cefotaxime showed a more rapid and complete bactericidal activity on E. coil K 12 than cephaloridine and cefazolin. In presence of the latters in fact, bacterial regrowth was observed after 24 hours. On S. aureus a complete killing activity of cefotaxime appeared at concentrations of 8 x MIC. A synergism seemed to exist between the complement dependent bactericidal activity of normal human serum and cephalosporins. E. coil K 12 (a rough strain) was killed by the combination of human serum and both cefotaxime and cefazolin at concentrations that were not bactericidal by themselves. Cephaloridine on the contrary showed an additive activity with normal human serum. Finally evidence that cefotaxime enhanced the bactericidal activity of human polymorphonuclear leukocytes against S. faecaiis, is reported.
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| first_indexed | 2024-04-13T19:51:44Z |
| format | Article |
| id | doaj.art-4290e7399dd74c7a8b51e91e76a2eced |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-13T19:51:44Z |
| publishDate | 1983-03-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-4290e7399dd74c7a8b51e91e76a2eced2022-12-22T02:32:29ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581983-03-014310.20344/amp.3790Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity.Giuliana Gialdroni Grassi0Patrizia Mangiarotti1Anna Fietta2Chair of Chemotherapy. Istituto Forlanini. University of Pavia. ItalyChair of Chemotherapy. Istituto Forlanini. University of Pavia. ItalyChair of Chemotherapy. Istituto Forlanini. University of Pavia. Italy Cefotaxime (HR 756) was compared with cefazolin and cephaloridine with regard to the rate of bacterial killing and to the influence on the bactericidal activity of human serum and polyrnorphonuclear leukocytes. At concentrations equal to 1-2 x MIC cefotaxime showed a more rapid and complete bactericidal activity on E. coil K 12 than cephaloridine and cefazolin. In presence of the latters in fact, bacterial regrowth was observed after 24 hours. On S. aureus a complete killing activity of cefotaxime appeared at concentrations of 8 x MIC. A synergism seemed to exist between the complement dependent bactericidal activity of normal human serum and cephalosporins. E. coil K 12 (a rough strain) was killed by the combination of human serum and both cefotaxime and cefazolin at concentrations that were not bactericidal by themselves. Cephaloridine on the contrary showed an additive activity with normal human serum. Finally evidence that cefotaxime enhanced the bactericidal activity of human polymorphonuclear leukocytes against S. faecaiis, is reported. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790 |
| spellingShingle | Giuliana Gialdroni Grassi Patrizia Mangiarotti Anna Fietta Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. Acta Médica Portuguesa |
| title | Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
| title_full | Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
| title_fullStr | Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
| title_full_unstemmed | Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
| title_short | Cefotaxime: rate of bacterial killing and interactions with serum and leukocyte activity. |
| title_sort | cefotaxime rate of bacterial killing and interactions with serum and leukocyte activity |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3790 |
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