Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Polyps
Underwater endoscopic mucosal resection (UEMR) has become a popular endoscopic resection method for large colorectal neoplasms. However, visualization can be poor during UEMR due to the presence of intestinal fluid. Gel immersion endoscopic mucosal resection (GIEMR), using a specially developed gel...
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MDPI AG
2023-03-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/711 |
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| author | Hiroshi Ashizawa Kinichi Hotta Kenichiro Imai Sayo Ito Yoshihiro Kishida Kazunori Takada Taishi Okumura Noboru Kawata Masao Yoshida Yuki Maeda Yoichi Yamamoto Tatsunori Minamide Junya Sato Hirotoshi Ishiwatari Hiroyuki Matsubayashi Hiroyuki Ono |
| author_facet | Hiroshi Ashizawa Kinichi Hotta Kenichiro Imai Sayo Ito Yoshihiro Kishida Kazunori Takada Taishi Okumura Noboru Kawata Masao Yoshida Yuki Maeda Yoichi Yamamoto Tatsunori Minamide Junya Sato Hirotoshi Ishiwatari Hiroyuki Matsubayashi Hiroyuki Ono |
| author_sort | Hiroshi Ashizawa |
| collection | DOAJ |
| description | Underwater endoscopic mucosal resection (UEMR) has become a popular endoscopic resection method for large colorectal neoplasms. However, visualization can be poor during UEMR due to the presence of intestinal fluid. Gel immersion endoscopic mucosal resection (GIEMR), using a specially developed gel (Viscoclear<sup>®</sup>, Otsuka Pharmaceutical Factory, Tokushima, Japan), can improve the visual field. However, reports of GIEMR for colorectal polyps are limited. Herein, we evaluated the short-term outcomes of GIEMR for non-pedunculated colorectal neoplasms (NPCRN). This single-center, retrospective, and observational study includes 25 lesions in 20 patients with NPCRN who underwent GIEMR between January and October 2022. The short-term outcomes and adverse events were evaluated. The lesion locations were as follows: right colon, 18 lesions; left colon, 7 lesions; and rectum, none. The median tumor diameter was 15 (IQR, 10–18) mm. Histological classification was as follows: sessile serrated lesion, 9 cases; adenoma, 12 cases; and intramucosal adenocarcinoma, 4 cases. The overall en bloc resection rates and R0 resection rates were 80% (20/25) and 72% (18/25). For NPCRN in 10–19 mm, the en bloc resection rate was 75% (12/16), with an R0 resection rate of 69% (11/16). No post-polypectomy bleeding, perforation, or post-coagulation syndrome were observed. The findings of our study provide preliminary evidence of the efficacy and safety of GIEMR for NPCRN. Therefore, GIEMR may be a promising novel endoscopic resection method for NPCRN. |
| first_indexed | 2024-03-11T06:17:06Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:06Z |
| publishDate | 2023-03-01 |
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| spelling | doaj.art-4290ef2e6f5a410eaaccbb4d12013cb02023-11-17T12:11:19ZengMDPI AGLife2075-17292023-03-0113371110.3390/life13030711Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal PolypsHiroshi Ashizawa0Kinichi Hotta1Kenichiro Imai2Sayo Ito3Yoshihiro Kishida4Kazunori Takada5Taishi Okumura6Noboru Kawata7Masao Yoshida8Yuki Maeda9Yoichi Yamamoto10Tatsunori Minamide11Junya Sato12Hirotoshi Ishiwatari13Hiroyuki Matsubayashi14Hiroyuki Ono15Division of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanDivision of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka 411-8777, JapanUnderwater endoscopic mucosal resection (UEMR) has become a popular endoscopic resection method for large colorectal neoplasms. However, visualization can be poor during UEMR due to the presence of intestinal fluid. Gel immersion endoscopic mucosal resection (GIEMR), using a specially developed gel (Viscoclear<sup>®</sup>, Otsuka Pharmaceutical Factory, Tokushima, Japan), can improve the visual field. However, reports of GIEMR for colorectal polyps are limited. Herein, we evaluated the short-term outcomes of GIEMR for non-pedunculated colorectal neoplasms (NPCRN). This single-center, retrospective, and observational study includes 25 lesions in 20 patients with NPCRN who underwent GIEMR between January and October 2022. The short-term outcomes and adverse events were evaluated. The lesion locations were as follows: right colon, 18 lesions; left colon, 7 lesions; and rectum, none. The median tumor diameter was 15 (IQR, 10–18) mm. Histological classification was as follows: sessile serrated lesion, 9 cases; adenoma, 12 cases; and intramucosal adenocarcinoma, 4 cases. The overall en bloc resection rates and R0 resection rates were 80% (20/25) and 72% (18/25). For NPCRN in 10–19 mm, the en bloc resection rate was 75% (12/16), with an R0 resection rate of 69% (11/16). No post-polypectomy bleeding, perforation, or post-coagulation syndrome were observed. The findings of our study provide preliminary evidence of the efficacy and safety of GIEMR for NPCRN. Therefore, GIEMR may be a promising novel endoscopic resection method for NPCRN.https://www.mdpi.com/2075-1729/13/3/711colorectal cancergel immersion endoscopic mucosal resectionnon-pedunculated colorectal neoplasms |
| spellingShingle | Hiroshi Ashizawa Kinichi Hotta Kenichiro Imai Sayo Ito Yoshihiro Kishida Kazunori Takada Taishi Okumura Noboru Kawata Masao Yoshida Yuki Maeda Yoichi Yamamoto Tatsunori Minamide Junya Sato Hirotoshi Ishiwatari Hiroyuki Matsubayashi Hiroyuki Ono Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Polyps Life colorectal cancer gel immersion endoscopic mucosal resection non-pedunculated colorectal neoplasms |
| title | Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Polyps |
| title_full | Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Polyps |
| title_fullStr | Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Polyps |
| title_full_unstemmed | Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Polyps |
| title_short | Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Non-Pedunculated Colorectal Polyps |
| title_sort | efficacy and safety of gel immersion endoscopic mucosal resection for non pedunculated colorectal polyps |
| topic | colorectal cancer gel immersion endoscopic mucosal resection non-pedunculated colorectal neoplasms |
| url | https://www.mdpi.com/2075-1729/13/3/711 |
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