Amino terminal recognition by a CCR6 chemokine receptor antibody blocks CCL20 signaling and IL-17 expression via β-arrestin

Amino terminal recognition by a CCR6 chemokine receptor antibody blocks CCL20 signaling and IL-17 expression via β-arrestin

Abstract Background CCR6 chemokine receptor is an important target in inflammatory diseases. Th17 cells express CCR6 and a number of inflammatory cytokines, including IL-17 and IL-22, which are involved in the propagation of inflammatory immune responses. CCR6 antagonist would be a potential treatme...

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Bibliographic Details
Main Authors: Sara Gómez-Melero, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Isaac Túnez-Fiñana, Elier Paz-Rojas
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Biotechnology
Subjects:
Th17 cells
CCR6
Inflammation
Therapeutic antibody
GPCR
Bias signaling
Online Access:https://doi.org/10.1186/s12896-021-00699-2

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