Alterations in homologous recombination repair genes in prostate cancer brain metastases
The diagnosis of prostate cancer brain metastasis (PCBM) has increased. Here, the authors investigate the landscape of somatic genetic alterations in brain metastases in a PCBM cohort of 51 patients with non-synchronous matched primary samples available for 20 patients.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30003-5 |
| _version_ | 1818194561791426560 |
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| author | Antonio Rodriguez-Calero John Gallon Dilara Akhoundova Sina Maletti Alison Ferguson Joanna Cyrta Ursula Amstutz Andrea Garofoli Viola Paradiso Scott A. Tomlins Ekkehard Hewer Vera Genitsch Achim Fleischmann Erik Vassella Elisabeth J. Rushing Rainer Grobholz Ingeborg Fischer Wolfram Jochum Gieri Cathomas Adeboye O. Osunkoya Lukas Bubendorf Holger Moch George Thalmann Charlotte K. Y. Ng Silke Gillessen Salvatore Piscuoglio Mark A. Rubin |
| author_facet | Antonio Rodriguez-Calero John Gallon Dilara Akhoundova Sina Maletti Alison Ferguson Joanna Cyrta Ursula Amstutz Andrea Garofoli Viola Paradiso Scott A. Tomlins Ekkehard Hewer Vera Genitsch Achim Fleischmann Erik Vassella Elisabeth J. Rushing Rainer Grobholz Ingeborg Fischer Wolfram Jochum Gieri Cathomas Adeboye O. Osunkoya Lukas Bubendorf Holger Moch George Thalmann Charlotte K. Y. Ng Silke Gillessen Salvatore Piscuoglio Mark A. Rubin |
| author_sort | Antonio Rodriguez-Calero |
| collection | DOAJ |
| description | The diagnosis of prostate cancer brain metastasis (PCBM) has increased. Here, the authors investigate the landscape of somatic genetic alterations in brain metastases in a PCBM cohort of 51 patients with non-synchronous matched primary samples available for 20 patients. |
| first_indexed | 2024-12-12T01:04:15Z |
| format | Article |
| id | doaj.art-42966ddd44de4ed4a87861f3d4c3176c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T01:04:15Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-42966ddd44de4ed4a87861f3d4c3176c2022-12-22T00:43:38ZengNature PortfolioNature Communications2041-17232022-05-0113111010.1038/s41467-022-30003-5Alterations in homologous recombination repair genes in prostate cancer brain metastasesAntonio Rodriguez-Calero0John Gallon1Dilara Akhoundova2Sina Maletti3Alison Ferguson4Joanna Cyrta5Ursula Amstutz6Andrea Garofoli7Viola Paradiso8Scott A. Tomlins9Ekkehard Hewer10Vera Genitsch11Achim Fleischmann12Erik Vassella13Elisabeth J. Rushing14Rainer Grobholz15Ingeborg Fischer16Wolfram Jochum17Gieri Cathomas18Adeboye O. Osunkoya19Lukas Bubendorf20Holger Moch21George Thalmann22Charlotte K. Y. Ng23Silke Gillessen24Salvatore Piscuoglio25Mark A. Rubin26Department for BioMedical Research, University of BernVisceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of BaselDepartment for BioMedical Research, University of BernDepartment for BioMedical Research, University of BernDepartment for BioMedical Research, University of BernDepartment of Pathology, Institut Curie, University Paris Sciences et LettresDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, University of BernInstitute of Medical Genetics and Pathology, University Hospital Basel, University of BaselInstitute of Medical Genetics and Pathology, University Hospital Basel, University of BaselDepartments of Pathology and Urology, University of Michigan Medical SchoolInstitute of Pathology, University of BernInstitute of Pathology, University of BernInstitute of Pathology, University of BernInstitute of Pathology, University of BernInstitute of Neuropathology, University Hospital ZurichInstitute of Pathology, Cantonal Hospital AarauInstitute of Pathology, Cantonal Hospital AarauInstitute of Pathology, Cantonal Hospital St. GallenInstitute of Pathology, Cantonal Hospital BasellandDepartments of Pathology and Laboratory Medicine, and Urology, Emory University School of MedicineInstitute of Medical Genetics and Pathology, University Hospital Basel, University of BaselDepartment of Pathology and Molecular Pathology, University Hospital ZurichDepartment of Urology, Inselspital, Bern University HospitalDepartment for BioMedical Research, University of BernFaculty of Biomedical Sciences, USIVisceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of BaselDepartment for BioMedical Research, University of BernThe diagnosis of prostate cancer brain metastasis (PCBM) has increased. Here, the authors investigate the landscape of somatic genetic alterations in brain metastases in a PCBM cohort of 51 patients with non-synchronous matched primary samples available for 20 patients.https://doi.org/10.1038/s41467-022-30003-5 |
| spellingShingle | Antonio Rodriguez-Calero John Gallon Dilara Akhoundova Sina Maletti Alison Ferguson Joanna Cyrta Ursula Amstutz Andrea Garofoli Viola Paradiso Scott A. Tomlins Ekkehard Hewer Vera Genitsch Achim Fleischmann Erik Vassella Elisabeth J. Rushing Rainer Grobholz Ingeborg Fischer Wolfram Jochum Gieri Cathomas Adeboye O. Osunkoya Lukas Bubendorf Holger Moch George Thalmann Charlotte K. Y. Ng Silke Gillessen Salvatore Piscuoglio Mark A. Rubin Alterations in homologous recombination repair genes in prostate cancer brain metastases Nature Communications |
| title | Alterations in homologous recombination repair genes in prostate cancer brain metastases |
| title_full | Alterations in homologous recombination repair genes in prostate cancer brain metastases |
| title_fullStr | Alterations in homologous recombination repair genes in prostate cancer brain metastases |
| title_full_unstemmed | Alterations in homologous recombination repair genes in prostate cancer brain metastases |
| title_short | Alterations in homologous recombination repair genes in prostate cancer brain metastases |
| title_sort | alterations in homologous recombination repair genes in prostate cancer brain metastases |
| url | https://doi.org/10.1038/s41467-022-30003-5 |
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