CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice

CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice

IntroductionA hallmark of T cell dysregulation during sepsis is the downregulation of costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered on memory T cells during sepsis. We recently showed that treatment with a αCD28 agonist in septic immunologically experie...

Full description

Bibliographic Details
Main Authors: Jerome C. Anyalebechi, Yini Sun, Carolyn Davis, Maylene E. Wagener, Zhe Liang, Eileen M. Burd, Craig M. Coopersmith, Mandy L. Ford
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
T lymhpocyte
sepsis
regulatory T Cell
costimulation
memory T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1346097/full

Similar Items

Similar Items