White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults
Inconsistency of performance across neuropsychological testing instruments (dispersion) shows sensitivity to acquired injury and neurodegenerative pathology in older adults. The underlying neural correlates have remained speculative however, in spite of known white matter degradation seen in conjunc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00352/full |
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| author | Drew W. R. Halliday Drew W. R. Halliday Jodie R. Gawryluk Jodie R. Gawryluk Mauricio A. Garcia-Barrera Mauricio A. Garcia-Barrera Stuart W. S. MacDonald Stuart W. S. MacDonald |
| author_facet | Drew W. R. Halliday Drew W. R. Halliday Jodie R. Gawryluk Jodie R. Gawryluk Mauricio A. Garcia-Barrera Mauricio A. Garcia-Barrera Stuart W. S. MacDonald Stuart W. S. MacDonald |
| author_sort | Drew W. R. Halliday |
| collection | DOAJ |
| description | Inconsistency of performance across neuropsychological testing instruments (dispersion) shows sensitivity to acquired injury and neurodegenerative pathology in older adults. The underlying neural correlates have remained speculative however, in spite of known white matter degradation seen in conjunction with elevated inconsistency in related operationalizations of intraindividual variability. Consistently, these operationalizations have controlled for artifactual age-related variance to increase measurement sensitivity of CNS dysfunction. In this study, dispersion was examined alongside composite scores of memory and executive functioning from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Forty-four healthy older adults (M = 72.0, SD = 6.4) underwent Diffusion Tensor Imaging (DTI) and neuropsychological testing spanning a range of cognitive domains. The results replicated previous findings, demonstrating reduced microstructural integrity with advanced age and increased integrity in high memory and executive functioning performers, across all major white matter tracts. With age first regressed from the composite scores, significant associations remained between greater executive functioning scores and greater microstructural integrity in the genu of the corpus callosum, right anterior corona radiata, anterior, posterior and rentrolenticular parts of right internal capsule, as well as right posterior thalamic radiation. With age regressed from the dispersion scores, greater values were primarily associated with decreased white matter integrity in the body and genu of corpus callosum, anterior corona radiata bilaterally and left superior longitudinal fasciculus. Dispersion is easily computed across speeded and accuracy-based measures and shows promise in detecting white matter damage, beyond that seen in the typical aging process. This appears to be the first investigation of neural correlates associated with increased dispersion. |
| first_indexed | 2024-12-11T01:25:20Z |
| format | Article |
| id | doaj.art-4297935843f94604a5d0d17c91be84a0 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-11T01:25:20Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-4297935843f94604a5d0d17c91be84a02022-12-22T01:25:32ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-10-011310.3389/fnhum.2019.00352479190White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older AdultsDrew W. R. Halliday0Drew W. R. Halliday1Jodie R. Gawryluk2Jodie R. Gawryluk3Mauricio A. Garcia-Barrera4Mauricio A. Garcia-Barrera5Stuart W. S. MacDonald6Stuart W. S. MacDonald7Department of Psychology, University of Victoria, Victoria, BC, CanadaInstitute on Aging and Lifelong Health, University of Victoria, Victoria, BC, CanadaDepartment of Psychology, University of Victoria, Victoria, BC, CanadaInstitute on Aging and Lifelong Health, University of Victoria, Victoria, BC, CanadaDepartment of Psychology, University of Victoria, Victoria, BC, CanadaInstitute on Aging and Lifelong Health, University of Victoria, Victoria, BC, CanadaDepartment of Psychology, University of Victoria, Victoria, BC, CanadaInstitute on Aging and Lifelong Health, University of Victoria, Victoria, BC, CanadaInconsistency of performance across neuropsychological testing instruments (dispersion) shows sensitivity to acquired injury and neurodegenerative pathology in older adults. The underlying neural correlates have remained speculative however, in spite of known white matter degradation seen in conjunction with elevated inconsistency in related operationalizations of intraindividual variability. Consistently, these operationalizations have controlled for artifactual age-related variance to increase measurement sensitivity of CNS dysfunction. In this study, dispersion was examined alongside composite scores of memory and executive functioning from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Forty-four healthy older adults (M = 72.0, SD = 6.4) underwent Diffusion Tensor Imaging (DTI) and neuropsychological testing spanning a range of cognitive domains. The results replicated previous findings, demonstrating reduced microstructural integrity with advanced age and increased integrity in high memory and executive functioning performers, across all major white matter tracts. With age first regressed from the composite scores, significant associations remained between greater executive functioning scores and greater microstructural integrity in the genu of the corpus callosum, right anterior corona radiata, anterior, posterior and rentrolenticular parts of right internal capsule, as well as right posterior thalamic radiation. With age regressed from the dispersion scores, greater values were primarily associated with decreased white matter integrity in the body and genu of corpus callosum, anterior corona radiata bilaterally and left superior longitudinal fasciculus. Dispersion is easily computed across speeded and accuracy-based measures and shows promise in detecting white matter damage, beyond that seen in the typical aging process. This appears to be the first investigation of neural correlates associated with increased dispersion.https://www.frontiersin.org/article/10.3389/fnhum.2019.00352/fulldiffusion tensor imaging (DTI)intraindividual variability (IIV)dispersionAlzheimer’s Disease Neuroimaging Initiative (ADNI)cognitive agingneuropsychological assessment |
| spellingShingle | Drew W. R. Halliday Drew W. R. Halliday Jodie R. Gawryluk Jodie R. Gawryluk Mauricio A. Garcia-Barrera Mauricio A. Garcia-Barrera Stuart W. S. MacDonald Stuart W. S. MacDonald White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults Frontiers in Human Neuroscience diffusion tensor imaging (DTI) intraindividual variability (IIV) dispersion Alzheimer’s Disease Neuroimaging Initiative (ADNI) cognitive aging neuropsychological assessment |
| title | White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults |
| title_full | White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults |
| title_fullStr | White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults |
| title_full_unstemmed | White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults |
| title_short | White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults |
| title_sort | white matter integrity is associated with intraindividual variability in neuropsychological test performance in healthy older adults |
| topic | diffusion tensor imaging (DTI) intraindividual variability (IIV) dispersion Alzheimer’s Disease Neuroimaging Initiative (ADNI) cognitive aging neuropsychological assessment |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00352/full |
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