Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease
Background: Recent studies have shown that renal disease is associated with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD), independent of traditional vascular risk factors. Although large artery lesions might be involved in the cerebrorenal association, evidence ha...
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| Format: | Article |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00498/full |
| _version_ | 1817978465458061312 |
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| author | Dong-Hui Ao Fei-Fei Zhai Fei Han Li-Xin Zhou Jun Ni Ming Yao Ding-Ding Zhang Ming-Li Li Xiao-Hong Fan Zheng-Yu Jin Li-Ying Cui Shu-Yang Zhang Yi-Cheng Zhu |
| author_facet | Dong-Hui Ao Fei-Fei Zhai Fei Han Li-Xin Zhou Jun Ni Ming Yao Ding-Ding Zhang Ming-Li Li Xiao-Hong Fan Zheng-Yu Jin Li-Ying Cui Shu-Yang Zhang Yi-Cheng Zhu |
| author_sort | Dong-Hui Ao |
| collection | DOAJ |
| description | Background: Recent studies have shown that renal disease is associated with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD), independent of traditional vascular risk factors. Although large artery lesions might be involved in the cerebrorenal association, evidence has been lacking.Methods: A total of 928 participants from a population-based cohort study were included. Kidney injury measurements included urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). CSVD was assessed on MRI by white matter hyperintensity volume (WMHV), lacunes, brain parenchymal fraction (BPF), cerebral microbleeds (CMBs), and perivascular space. Carotid plaques and brachial-ankle pulse wave velocity (baPWV) were used to assess large artery atherosclerosis and stiffness. Multivariable linear and logistic regression and additional interaction models were used for statistical analysis.Results: Individuals with elevated ACR had higher prevalence of lacunes and more WMHV (p = 0.001 and 0.000, respectively), those with decreased eGFR had smaller brain volume, higher prevalence of lacunes and deep CMBs (p = 0.009, p = 0.017) and p = 0.010 respectively). Interaction analysis revealed that carotid plaque and baPWV significantly enhanced the association between eGFR and BPF (p = 0.001 and p = 0.002, respectively), that is, the association of eGFR with BPF was only significant among participants with carotid plaque and higher baPWV. In addition, carotid plaque enhanced the association between ACR and WMHV (p = 0.034) and baPWV enhanced the association between ACR and the presence of lacunes (p = 0.027). Modifying effect of large vessel disease markers on the association between kidney injury measurements and CMBs was not significant.Conclusion: Evaluation of subclinical CVSD in individuals with kidney injury is warranted, especially in those with combined large artery disease. |
| first_indexed | 2024-04-13T22:30:30Z |
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| id | doaj.art-42996fe017c4429997f8e750cb744205 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T22:30:30Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-42996fe017c4429997f8e750cb7442052022-12-22T02:26:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-06-01910.3389/fneur.2018.00498367113Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel DiseaseDong-Hui Ao0Fei-Fei Zhai1Fei Han2Li-Xin Zhou3Jun Ni4Ming Yao5Ding-Ding Zhang6Ming-Li Li7Xiao-Hong Fan8Zheng-Yu Jin9Li-Ying Cui10Shu-Yang Zhang11Yi-Cheng Zhu12Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCentral Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCentral Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBackground: Recent studies have shown that renal disease is associated with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD), independent of traditional vascular risk factors. Although large artery lesions might be involved in the cerebrorenal association, evidence has been lacking.Methods: A total of 928 participants from a population-based cohort study were included. Kidney injury measurements included urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). CSVD was assessed on MRI by white matter hyperintensity volume (WMHV), lacunes, brain parenchymal fraction (BPF), cerebral microbleeds (CMBs), and perivascular space. Carotid plaques and brachial-ankle pulse wave velocity (baPWV) were used to assess large artery atherosclerosis and stiffness. Multivariable linear and logistic regression and additional interaction models were used for statistical analysis.Results: Individuals with elevated ACR had higher prevalence of lacunes and more WMHV (p = 0.001 and 0.000, respectively), those with decreased eGFR had smaller brain volume, higher prevalence of lacunes and deep CMBs (p = 0.009, p = 0.017) and p = 0.010 respectively). Interaction analysis revealed that carotid plaque and baPWV significantly enhanced the association between eGFR and BPF (p = 0.001 and p = 0.002, respectively), that is, the association of eGFR with BPF was only significant among participants with carotid plaque and higher baPWV. In addition, carotid plaque enhanced the association between ACR and WMHV (p = 0.034) and baPWV enhanced the association between ACR and the presence of lacunes (p = 0.027). Modifying effect of large vessel disease markers on the association between kidney injury measurements and CMBs was not significant.Conclusion: Evaluation of subclinical CVSD in individuals with kidney injury is warranted, especially in those with combined large artery disease.https://www.frontiersin.org/article/10.3389/fneur.2018.00498/fulllarge artery atherosclerosisartery stiffnesskidney injurycerebral small vessel diseaseinteraction |
| spellingShingle | Dong-Hui Ao Fei-Fei Zhai Fei Han Li-Xin Zhou Jun Ni Ming Yao Ding-Ding Zhang Ming-Li Li Xiao-Hong Fan Zheng-Yu Jin Li-Ying Cui Shu-Yang Zhang Yi-Cheng Zhu Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease Frontiers in Neurology large artery atherosclerosis artery stiffness kidney injury cerebral small vessel disease interaction |
| title | Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease |
| title_full | Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease |
| title_fullStr | Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease |
| title_full_unstemmed | Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease |
| title_short | Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease |
| title_sort | large vessel disease modifies the relationship between kidney injury and cerebral small vessel disease |
| topic | large artery atherosclerosis artery stiffness kidney injury cerebral small vessel disease interaction |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00498/full |
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