Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation
Objective: It is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS). Methods: Fifteen adults with PCS...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Clinical Neurophysiology Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2467981X2030024X |
| _version_ | 1818385477335515136 |
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| author | Mitchell B. Locke Stephen L. Toepp Claudia V. Turco Diana H. Harasym Michel P. Rathbone Michael D. Noseworthy Aimee J. Nelson |
| author_facet | Mitchell B. Locke Stephen L. Toepp Claudia V. Turco Diana H. Harasym Michel P. Rathbone Michael D. Noseworthy Aimee J. Nelson |
| author_sort | Mitchell B. Locke |
| collection | DOAJ |
| description | Objective: It is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS). Methods: Fifteen adults with PCS and 13 healthy, non-injured adults were tested. All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant motor cortex. Results: Cortical silent period (p = 0.02, g = 0.96) and ipsilateral silent period (p = 0.04, g = 0.78) were shorter in the PCS group compared to the control group which may reflect reduced GABA-mediated inhibition in PCS. Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere. Conclusions: These data suggest that persistent neurophysiological differences are present in those with PCS. The exact contributing factors to such changes remain to be investigated by future studies. Significance: This study provides novel evidence of lasting neurophysiological changes in PCS. |
| first_indexed | 2024-12-14T03:38:47Z |
| format | Article |
| id | doaj.art-429a0747f7b1413c82215dcafd70a872 |
| institution | Directory Open Access Journal |
| issn | 2467-981X |
| language | English |
| last_indexed | 2024-12-14T03:38:47Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Neurophysiology Practice |
| spelling | doaj.art-429a0747f7b1413c82215dcafd70a8722022-12-21T23:18:33ZengElsevierClinical Neurophysiology Practice2467-981X2020-01-015157164Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulationMitchell B. Locke0Stephen L. Toepp1Claudia V. Turco2Diana H. Harasym3Michel P. Rathbone4Michael D. Noseworthy5Aimee J. Nelson6Department of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, CanadaDepartment of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, CanadaDepartment of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, CanadaSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario L8S 4L8, CanadaDepartment of Medicine, Division of Neurology, McMaster University, Hamilton, Ontario L8N 3Z5, CanadaSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario L8S 4L8, Canada; Department of Electrical and Computer Engineering, McMaster University, Hamilton, Ontario L8S 4K1, Canada; Imaging Research Centre, St. Joseph’s Healthcare, Hamilton, Ontario L8N 4A6, CanadaDepartment of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, Canada; Corresponding author.Objective: It is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS). Methods: Fifteen adults with PCS and 13 healthy, non-injured adults were tested. All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant motor cortex. Results: Cortical silent period (p = 0.02, g = 0.96) and ipsilateral silent period (p = 0.04, g = 0.78) were shorter in the PCS group compared to the control group which may reflect reduced GABA-mediated inhibition in PCS. Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere. Conclusions: These data suggest that persistent neurophysiological differences are present in those with PCS. The exact contributing factors to such changes remain to be investigated by future studies. Significance: This study provides novel evidence of lasting neurophysiological changes in PCS.http://www.sciencedirect.com/science/article/pii/S2467981X2030024XTranscranial magnetic stimulationPost-concussion syndromeConcussionInhibitionMotor cortex |
| spellingShingle | Mitchell B. Locke Stephen L. Toepp Claudia V. Turco Diana H. Harasym Michel P. Rathbone Michael D. Noseworthy Aimee J. Nelson Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation Clinical Neurophysiology Practice Transcranial magnetic stimulation Post-concussion syndrome Concussion Inhibition Motor cortex |
| title | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
| title_full | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
| title_fullStr | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
| title_full_unstemmed | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
| title_short | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
| title_sort | altered motor system function in post concussion syndrome as assessed via transcranial magnetic stimulation |
| topic | Transcranial magnetic stimulation Post-concussion syndrome Concussion Inhibition Motor cortex |
| url | http://www.sciencedirect.com/science/article/pii/S2467981X2030024X |
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