An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancer
Cancer is the most challenging global health issue despite advancement in new drug development and biological understanding of oncology. Metastasis is the hallmark of cancer development resulting in huge death and it remained poorly understood. Various research articles published to control cancer a...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Advances in Cancer Biology - Metastasis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667394023000175 |
| _version_ | 1797799886123433984 |
|---|---|
| author | Mrunali Patil Afzal Hussain Mohammad A. Altamimi Sumel Ashique Nazima Haider Abdul Faruk Tahir Khuroo Abdulla Sherikar Mohd Usman Mohd Siddique Azim Ansari Tabassum Khair Barbhuiya |
| author_facet | Mrunali Patil Afzal Hussain Mohammad A. Altamimi Sumel Ashique Nazima Haider Abdul Faruk Tahir Khuroo Abdulla Sherikar Mohd Usman Mohd Siddique Azim Ansari Tabassum Khair Barbhuiya |
| author_sort | Mrunali Patil |
| collection | DOAJ |
| description | Cancer is the most challenging global health issue despite advancement in new drug development and biological understanding of oncology. Metastasis is the hallmark of cancer development resulting in huge death and it remained poorly understood. Various research articles published to control cancer and metastasis using lipidic nanocarriers so far. However, safety and high patient compliance are the prime concern. Medication is always of major concern for a clinician before prescribing any dosage form or drug. The high toxicity profile of anticancer drugs led to increased financial burden of treatment, mortality and complex consequences. Therefore, conventional dosage forms failed to culminate various issues related to therapeutic efficacy and drug related toxicity. Then, many researchers tried the novel drug delivery systems for effective and safe targeting of anticancer drugs. Exosomes, vesicular systems, and erythrocytes have been explored to treat cancer. It was imperative to compile major findings from these researches carried out so far. In the review, we highlighted application of exosomes, liposomes, and erythrocytes to control metastasis and cancer. Moreover, we have addressed various critical attributes of liposomes while formulation design for improved therapeutic efficacy and mechanistic perspective for drug targeting using the described vesicular carriers. Finally, we compiled major findings of clinical data published in clinical research plate-form. This review highlighted the major findings associated with nanovesicles based tumor targeting in which anticancer drugs are encapsulated in suitable vesicular systems and reach to site specific delivery of drugs. |
| first_indexed | 2024-03-13T04:25:41Z |
| format | Article |
| id | doaj.art-429a7ec210f24dcfa48500b6ec86c2cc |
| institution | Directory Open Access Journal |
| issn | 2667-3940 |
| language | English |
| last_indexed | 2024-03-13T04:25:41Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Cancer Biology - Metastasis |
| spelling | doaj.art-429a7ec210f24dcfa48500b6ec86c2cc2023-06-20T04:21:30ZengElsevierAdvances in Cancer Biology - Metastasis2667-39402023-07-017100103An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancerMrunali Patil0Afzal Hussain1Mohammad A. Altamimi2Sumel Ashique3Nazima Haider4Abdul Faruk5Tahir Khuroo6Abdulla Sherikar7Mohd Usman Mohd Siddique8Azim Ansari9Tabassum Khair Barbhuiya10Department of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, MH, 424001, IndiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; Corresponding author.Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi ArabiaDepartment of Pharmaceutics, Bharat Institute of Technology, School of Pharmacy, Meerut, UP, IndiaDepartment of Pathology, College of Medicine, King Khalid University, Abha, 61421, Saudi ArabiaDepartment of Pharmaceutical Science, HNB Garhwal University (A Central University), Srinagar, Uttarakhand, IndiaPGx Global Foundation, 5600 S Willow Dr , Houston, Texas, 77035, USADepartment of Pharmacology, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, MH, 424001, IndiaDepartment of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, MH, 424001, IndiaDepartment of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, MH, 424001, IndiaCenter for Genomic and Personalized Health, School of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD, 4000, AustraliaCancer is the most challenging global health issue despite advancement in new drug development and biological understanding of oncology. Metastasis is the hallmark of cancer development resulting in huge death and it remained poorly understood. Various research articles published to control cancer and metastasis using lipidic nanocarriers so far. However, safety and high patient compliance are the prime concern. Medication is always of major concern for a clinician before prescribing any dosage form or drug. The high toxicity profile of anticancer drugs led to increased financial burden of treatment, mortality and complex consequences. Therefore, conventional dosage forms failed to culminate various issues related to therapeutic efficacy and drug related toxicity. Then, many researchers tried the novel drug delivery systems for effective and safe targeting of anticancer drugs. Exosomes, vesicular systems, and erythrocytes have been explored to treat cancer. It was imperative to compile major findings from these researches carried out so far. In the review, we highlighted application of exosomes, liposomes, and erythrocytes to control metastasis and cancer. Moreover, we have addressed various critical attributes of liposomes while formulation design for improved therapeutic efficacy and mechanistic perspective for drug targeting using the described vesicular carriers. Finally, we compiled major findings of clinical data published in clinical research plate-form. This review highlighted the major findings associated with nanovesicles based tumor targeting in which anticancer drugs are encapsulated in suitable vesicular systems and reach to site specific delivery of drugs.http://www.sciencedirect.com/science/article/pii/S2667394023000175Cancer and metastasisVesicular systemsExosomesErythrocytesMechanistic perspectivesCritical attributes |
| spellingShingle | Mrunali Patil Afzal Hussain Mohammad A. Altamimi Sumel Ashique Nazima Haider Abdul Faruk Tahir Khuroo Abdulla Sherikar Mohd Usman Mohd Siddique Azim Ansari Tabassum Khair Barbhuiya An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancer Advances in Cancer Biology - Metastasis Cancer and metastasis Vesicular systems Exosomes Erythrocytes Mechanistic perspectives Critical attributes |
| title | An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancer |
| title_full | An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancer |
| title_fullStr | An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancer |
| title_full_unstemmed | An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancer |
| title_short | An insight of various vesicular systems, erythrosomes, and exosomes to control metastasis and cancer |
| title_sort | insight of various vesicular systems erythrosomes and exosomes to control metastasis and cancer |
| topic | Cancer and metastasis Vesicular systems Exosomes Erythrocytes Mechanistic perspectives Critical attributes |
| url | http://www.sciencedirect.com/science/article/pii/S2667394023000175 |
| work_keys_str_mv | AT mrunalipatil aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT afzalhussain aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT mohammadaaltamimi aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT sumelashique aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT nazimahaider aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT abdulfaruk aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT tahirkhuroo aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT abdullasherikar aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT mohdusmanmohdsiddique aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT azimansari aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT tabassumkhairbarbhuiya aninsightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT mrunalipatil insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT afzalhussain insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT mohammadaaltamimi insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT sumelashique insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT nazimahaider insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT abdulfaruk insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT tahirkhuroo insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT abdullasherikar insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT mohdusmanmohdsiddique insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT azimansari insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer AT tabassumkhairbarbhuiya insightofvariousvesicularsystemserythrosomesandexosomestocontrolmetastasisandcancer |