Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La Libertad
Objective: To identify demographic, clinical, laboratory and treatment characteristics associated with mortality in hospitalized patients with SARS-CoV-2 pneumonia in a Level I Hospital of Peruvian Social Security, at La Libertad Network. Materials and Method: Retrospective cohort study. Cox propor...
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| Format: | Article |
| Language: | English |
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Colegio Médico del Perú
2022-08-01
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| Series: | Acta Médica Peruana |
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| Online Access: | https://amp.cmp.org.pe/index.php/AMP/article/view/2336 |
| _version_ | 1797786487142481920 |
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| author | César Alejandro Arana-Calderón Sandra Paola Chávez-Guevara |
| author_facet | César Alejandro Arana-Calderón Sandra Paola Chávez-Guevara |
| author_sort | César Alejandro Arana-Calderón |
| collection | DOAJ |
| description |
Objective: To identify demographic, clinical, laboratory and treatment characteristics associated with mortality in hospitalized patients with SARS-CoV-2 pneumonia in a Level I Hospital of Peruvian Social Security, at La Libertad Network. Materials and Method: Retrospective cohort study. Cox proportional hazards model was used, calculating crude and adjusted hazard ratios (HR), and the Kaplan-Meier estimator was used to evaluate the overall survival curve and for each factor. Results: Of the 158 patients, the diagnosis was confirmed in 79.11%. Nearly 70% (68.99%) were men, the global median age was 65 years (IQR: 52-77), and it was higher in deceased subjects 69 years old (IQR: 61-80 years). Little more than half of this population (53.80%) had comorbidities, such as high blood pressure (27.85%), obesity (22.78%), and diabetes mellitus (13.92%). The median duration of symptoms prior to admission was 9 days (IQR: 6-11 days). HRs were determined for oxygen saturation less than 80% on admission with 0.21 FIO2, leukocytosis with associated lymphopenia, oxygen requirement at 0.80 FIO2 on admission, and moderate-severe ARDS. Such values were 1.54, 1.98, 2.07 and 2.91, respectively. Conclusions: The development of moderate-severe ARDS on admission, leukocytosis associated with lymphopenia, less than 80% hypoxemia on admission at 0.21 FIO2, and high-flow oxygen requirement since admission with 0.80 FIO2, were the only risk factors for mortality.
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| first_indexed | 2024-03-13T01:08:39Z |
| format | Article |
| id | doaj.art-429aad22c59a450f8a6020f3a5b9fae7 |
| institution | Directory Open Access Journal |
| issn | 1018-8800 1728-5917 |
| language | English |
| last_indexed | 2024-03-13T01:08:39Z |
| publishDate | 2022-08-01 |
| publisher | Colegio Médico del Perú |
| record_format | Article |
| series | Acta Médica Peruana |
| spelling | doaj.art-429aad22c59a450f8a6020f3a5b9fae72023-07-06T05:49:26ZengColegio Médico del PerúActa Médica Peruana1018-88001728-59172022-08-0139210.35663/amp.2022.392.23362336Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La LibertadCésar Alejandro Arana-Calderón0Sandra Paola Chávez-Guevara1Hospital I Pacasmayo-Essalud - Red La Libertad, Universidad Peruana Cayetano HerediaUniversidad Privada Antenor Orrego Objective: To identify demographic, clinical, laboratory and treatment characteristics associated with mortality in hospitalized patients with SARS-CoV-2 pneumonia in a Level I Hospital of Peruvian Social Security, at La Libertad Network. Materials and Method: Retrospective cohort study. Cox proportional hazards model was used, calculating crude and adjusted hazard ratios (HR), and the Kaplan-Meier estimator was used to evaluate the overall survival curve and for each factor. Results: Of the 158 patients, the diagnosis was confirmed in 79.11%. Nearly 70% (68.99%) were men, the global median age was 65 years (IQR: 52-77), and it was higher in deceased subjects 69 years old (IQR: 61-80 years). Little more than half of this population (53.80%) had comorbidities, such as high blood pressure (27.85%), obesity (22.78%), and diabetes mellitus (13.92%). The median duration of symptoms prior to admission was 9 days (IQR: 6-11 days). HRs were determined for oxygen saturation less than 80% on admission with 0.21 FIO2, leukocytosis with associated lymphopenia, oxygen requirement at 0.80 FIO2 on admission, and moderate-severe ARDS. Such values were 1.54, 1.98, 2.07 and 2.91, respectively. Conclusions: The development of moderate-severe ARDS on admission, leukocytosis associated with lymphopenia, less than 80% hypoxemia on admission at 0.21 FIO2, and high-flow oxygen requirement since admission with 0.80 FIO2, were the only risk factors for mortality. https://amp.cmp.org.pe/index.php/AMP/article/view/2336SARS-CoV-2COVID-19Risk FactorsCoronavirus InfectionsHospitalizationMortality |
| spellingShingle | César Alejandro Arana-Calderón Sandra Paola Chávez-Guevara Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La Libertad Acta Médica Peruana SARS-CoV-2 COVID-19 Risk Factors Coronavirus Infections Hospitalization Mortality |
| title | Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La Libertad |
| title_full | Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La Libertad |
| title_fullStr | Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La Libertad |
| title_full_unstemmed | Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La Libertad |
| title_short | Risk factors associated with mortality in patients with SARS-CoV-2 pneumonia in a Level I Social Security Hospital, Peru-La Libertad |
| title_sort | risk factors associated with mortality in patients with sars cov 2 pneumonia in a level i social security hospital peru la libertad |
| topic | SARS-CoV-2 COVID-19 Risk Factors Coronavirus Infections Hospitalization Mortality |
| url | https://amp.cmp.org.pe/index.php/AMP/article/view/2336 |
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