Mutant Huntingtin Derails Cysteine Metabolism in Huntington’s Disease at Both Transcriptional and Post-Translational Levels
Cysteine is a semi-essential amino acid that not only plays an essential role as a component of protein synthesis, but also in the generation of numerous sulfur-containing molecules such as the antioxidant glutathione and coenzyme A. We previously showed that the metabolism of cysteine is dysregulat...
Main Authors: | Bindu D. Paul, Juan I. Sbodio, Solomon H. Snyder |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-07-01
|
Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/11/8/1470 |
Similar Items
-
Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease
by: Bindu D. Paul
Published: (2021-09-01) -
Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
by: Gethin J. McBean
Published: (2017-08-01) -
The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
by: Joseph A. Combs, et al.
Published: (2019-05-01) -
Interplay between Sulfur Assimilation and Biodesulfurization Activity in Rhodococcus qingshengii IGTS8: Insights into a Regulatory Role of the Reverse Transsulfuration Pathway
by: Olga Martzoukou, et al.
Published: (2022-08-01) -
MYCN upregulates the transsulfuration pathway to suppress the ferroptotic vulnerability in MYCN-amplified neuroblastoma
by: Konstantinos V. Floros, et al.
Published: (2022-01-01)