COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIOD
In total, 316 patients with Q wave myocardial infarction (MI) were randomised into three groups. For six months after hospital discharge, 103 patients from the control group received standard therapy (aspirin, enalapril, metoprolol, and simvastatin). Group 1 (n=103) also received trimetazidine, and...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2011-08-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1128 |
| _version_ | 1826561483168808960 |
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| author | R. M. Gafurova U. A. Islamova A. A. Abdullaev |
| author_facet | R. M. Gafurova U. A. Islamova A. A. Abdullaev |
| author_sort | R. M. Gafurova |
| collection | DOAJ |
| description | In total, 316 patients with Q wave myocardial infarction (MI) were randomised into three groups. For six months after hospital discharge, 103 patients from the control group received standard therapy (aspirin, enalapril, metoprolol, and simvastatin). Group 1 (n=103) also received trimetazidine, and Group 2 (n=206) was administered ramipril, carvedilol, and trimetazidine. The end-point incidence was assessed during the two-year follow-up period (repeat MI, unstable angina, death, and the combination of these end-points). The Group 2 therapy (ramipril, carvedilol, and trimetazidine) was the most effective in terms of the end-point incidence reduction. The effectiveness of the Group 1 treatment (enalapril, metoprolol, and trimetazidine) was slightly lower, while the control group therapy (standard treatment, plus enalapril and metoprolol) was the least effective. |
| first_indexed | 2024-04-09T20:51:52Z |
| format | Article |
| id | doaj.art-429bd1c53ff640df9d21645051e34803 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:32:53Z |
| publishDate | 2011-08-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-429bd1c53ff640df9d21645051e348032025-03-02T11:42:29Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202011-08-01048590933COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIODR. M. Gafurova0U. A. Islamova1A. A. Abdullaev2ГОУ ВПО Дагестанская государственная медицинская академия МЗ и СР РФ, МахачкалаГОУ ВПО Дагестанская государственная медицинская академия МЗ и СР РФ, МахачкалаГОУ ВПО Дагестанская государственная медицинская академия МЗ и СР РФ, МахачкалаIn total, 316 patients with Q wave myocardial infarction (MI) were randomised into three groups. For six months after hospital discharge, 103 patients from the control group received standard therapy (aspirin, enalapril, metoprolol, and simvastatin). Group 1 (n=103) also received trimetazidine, and Group 2 (n=206) was administered ramipril, carvedilol, and trimetazidine. The end-point incidence was assessed during the two-year follow-up period (repeat MI, unstable angina, death, and the combination of these end-points). The Group 2 therapy (ramipril, carvedilol, and trimetazidine) was the most effective in terms of the end-point incidence reduction. The effectiveness of the Group 1 treatment (enalapril, metoprolol, and trimetazidine) was slightly lower, while the control group therapy (standard treatment, plus enalapril and metoprolol) was the least effective.https://russjcardiol.elpub.ru/jour/article/view/1128end-pointspost-infarction periodmyocardial infarctionramipril, carvediloltrimetazidineenalaprilmetoprolol |
| spellingShingle | R. M. Gafurova U. A. Islamova A. A. Abdullaev COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIOD Российский кардиологический журнал end-points post-infarction period myocardial infarction ramipril, carvedilol trimetazidine enalapril metoprolol |
| title | COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIOD |
| title_full | COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIOD |
| title_fullStr | COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIOD |
| title_full_unstemmed | COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIOD |
| title_short | COMPARATIVE EFFECTIVENESS OF DIFFERENT DRUG COMBINATIONS IN REGARD TO END-POINT INCIDENCE DURING POST-INFARCTION PERIOD |
| title_sort | comparative effectiveness of different drug combinations in regard to end point incidence during post infarction period |
| topic | end-points post-infarction period myocardial infarction ramipril, carvedilol trimetazidine enalapril metoprolol |
| url | https://russjcardiol.elpub.ru/jour/article/view/1128 |
| work_keys_str_mv | AT rmgafurova comparativeeffectivenessofdifferentdrugcombinationsinregardtoendpointincidenceduringpostinfarctionperiod AT uaislamova comparativeeffectivenessofdifferentdrugcombinationsinregardtoendpointincidenceduringpostinfarctionperiod AT aaabdullaev comparativeeffectivenessofdifferentdrugcombinationsinregardtoendpointincidenceduringpostinfarctionperiod |