Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors
The available interventions for people who are at risk of suicide have limited efficacy. Recently, research on new mental health treatments has started to consider psychedelic compounds, particularly psilocybin, a molecule with a few thousand years of history of use in human societies. The possible...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/12/1213 |
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| author | Robertas Strumila Bénédicte Nobile Laura Korsakova Aiste Lengvenyte Emilie Olie Jorge Lopez-Castroman Sébastien Guillaume Philippe Courtet |
| author_facet | Robertas Strumila Bénédicte Nobile Laura Korsakova Aiste Lengvenyte Emilie Olie Jorge Lopez-Castroman Sébastien Guillaume Philippe Courtet |
| author_sort | Robertas Strumila |
| collection | DOAJ |
| description | The available interventions for people who are at risk of suicide have limited efficacy. Recently, research on new mental health treatments has started to consider psychedelic compounds, particularly psilocybin, a molecule with a few thousand years of history of use in human societies. The possible effects of psilocybin on suicidal ideation and behaviors have not been specifically studied yet; however, the current knowledge on the suicidal process and the available data on es/ketamine suggest that psylocibin could be used to modulate the thoughts and behavioral patterns in individuals who are at risk of suicidal behaviors. Here, we summarize the available evidence on the possible mechanisms underlying psilocybin positive effects on suicide risk. Major pathways related to suicidal behaviors that might be modulated by psylocibin include serotonin receptors. Specifically, psylocibin directly stimulates the serotonin 2A receptor (5HT<sub>2A</sub>), targeting the inflammatory and oxidative stress pathways and leading to a rapid increase in brain plasticity and inflammation suppression and increases in cognitive flexibility, spirituality, and empathy. We also present preliminary epidemiological data and provide a rationale for studying psilocybin in individuals with suicidal ideation or who are at risk of suicidal behaviors. This review presents a framework to understand the basis for psilocybin use in individuals who are at risk of suicidal behaviors and calls for clinical studies. |
| first_indexed | 2024-03-10T03:21:17Z |
| format | Article |
| id | doaj.art-429c33f2b6aa437c92aa67121276c0c6 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:21:17Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-429c33f2b6aa437c92aa67121276c0c62023-11-23T10:02:32ZengMDPI AGPharmaceuticals1424-82472021-11-011412121310.3390/ph14121213Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal BehaviorsRobertas Strumila0Bénédicte Nobile1Laura Korsakova2Aiste Lengvenyte3Emilie Olie4Jorge Lopez-Castroman5Sébastien Guillaume6Philippe Courtet7Department of Urgent and Post Urgent Psychiatry, CHU Montpellier, 34000 Montpellier, FranceDepartment of Urgent and Post Urgent Psychiatry, CHU Montpellier, 34000 Montpellier, FranceLaboratory of Preclinical Drug Investigation, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, LithuaniaDepartment of Urgent and Post Urgent Psychiatry, CHU Montpellier, 34000 Montpellier, FranceDepartment of Urgent and Post Urgent Psychiatry, CHU Montpellier, 34000 Montpellier, FranceInstitute of Functional Genomics, CNRS, INSERM, University of Montpellier, 34295 Montpellier, FranceDepartment of Urgent and Post Urgent Psychiatry, CHU Montpellier, 34000 Montpellier, FranceDepartment of Urgent and Post Urgent Psychiatry, CHU Montpellier, 34000 Montpellier, FranceThe available interventions for people who are at risk of suicide have limited efficacy. Recently, research on new mental health treatments has started to consider psychedelic compounds, particularly psilocybin, a molecule with a few thousand years of history of use in human societies. The possible effects of psilocybin on suicidal ideation and behaviors have not been specifically studied yet; however, the current knowledge on the suicidal process and the available data on es/ketamine suggest that psylocibin could be used to modulate the thoughts and behavioral patterns in individuals who are at risk of suicidal behaviors. Here, we summarize the available evidence on the possible mechanisms underlying psilocybin positive effects on suicide risk. Major pathways related to suicidal behaviors that might be modulated by psylocibin include serotonin receptors. Specifically, psylocibin directly stimulates the serotonin 2A receptor (5HT<sub>2A</sub>), targeting the inflammatory and oxidative stress pathways and leading to a rapid increase in brain plasticity and inflammation suppression and increases in cognitive flexibility, spirituality, and empathy. We also present preliminary epidemiological data and provide a rationale for studying psilocybin in individuals with suicidal ideation or who are at risk of suicidal behaviors. This review presents a framework to understand the basis for psilocybin use in individuals who are at risk of suicidal behaviors and calls for clinical studies.https://www.mdpi.com/1424-8247/14/12/1213psilocybinsuicidalitysuicidal behaviorspsychedelicspsychiatryserotonin |
| spellingShingle | Robertas Strumila Bénédicte Nobile Laura Korsakova Aiste Lengvenyte Emilie Olie Jorge Lopez-Castroman Sébastien Guillaume Philippe Courtet Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors Pharmaceuticals psilocybin suicidality suicidal behaviors psychedelics psychiatry serotonin |
| title | Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors |
| title_full | Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors |
| title_fullStr | Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors |
| title_full_unstemmed | Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors |
| title_short | Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors |
| title_sort | psilocybin a naturally occurring indoleamine compound could be useful to prevent suicidal behaviors |
| topic | psilocybin suicidality suicidal behaviors psychedelics psychiatry serotonin |
| url | https://www.mdpi.com/1424-8247/14/12/1213 |
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