MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance
Despite substantial progress in cancer therapy, colorectal cancer (CRC) is still the third leading cause of cancer death worldwide, mainly due to the acquisition of resistance and disease recurrence in patients. Growing evidence indicates that deregulation of hormone signaling pathways and their cro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/1/39 |
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| author | Crescenzo Massaro Elham Safadeh Giulia Sgueglia Hendrik G. Stunnenberg Lucia Altucci Carmela Dell’Aversana |
| author_facet | Crescenzo Massaro Elham Safadeh Giulia Sgueglia Hendrik G. Stunnenberg Lucia Altucci Carmela Dell’Aversana |
| author_sort | Crescenzo Massaro |
| collection | DOAJ |
| description | Despite substantial progress in cancer therapy, colorectal cancer (CRC) is still the third leading cause of cancer death worldwide, mainly due to the acquisition of resistance and disease recurrence in patients. Growing evidence indicates that deregulation of hormone signaling pathways and their cross-talk with other signaling cascades inside CRC cells may have an impact on therapy resistance. MicroRNAs (miRNAs) are small conserved non-coding RNAs thatfunction as negative regulators in many gene expression processes. Key studies have identified miRNA alterations in cancer progression and drug resistance. In this review, we provide a comprehensive overview and assessment of miRNAs role in hormone signaling pathways in CRC drug resistance and their potential as future targets for overcoming resistance to treatment. |
| first_indexed | 2024-03-10T13:40:31Z |
| format | Article |
| id | doaj.art-429f260c395e41a6800ed8c99bb5b79f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:40:31Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-429f260c395e41a6800ed8c99bb5b79f2023-11-21T03:03:50ZengMDPI AGCells2073-44092020-12-011013910.3390/cells10010039MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer ResistanceCrescenzo Massaro0Elham Safadeh1Giulia Sgueglia2Hendrik G. Stunnenberg3Lucia Altucci4Carmela Dell’Aversana5Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyPrinses Maxima Centrum, Heidelberglaan 25, 3584 CS Utrecht, The NetherlandsDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via De Crecchio, 7, 80138 Naples, ItalyDespite substantial progress in cancer therapy, colorectal cancer (CRC) is still the third leading cause of cancer death worldwide, mainly due to the acquisition of resistance and disease recurrence in patients. Growing evidence indicates that deregulation of hormone signaling pathways and their cross-talk with other signaling cascades inside CRC cells may have an impact on therapy resistance. MicroRNAs (miRNAs) are small conserved non-coding RNAs thatfunction as negative regulators in many gene expression processes. Key studies have identified miRNA alterations in cancer progression and drug resistance. In this review, we provide a comprehensive overview and assessment of miRNAs role in hormone signaling pathways in CRC drug resistance and their potential as future targets for overcoming resistance to treatment.https://www.mdpi.com/2073-4409/10/1/39microRNAhormone signalingcolorectal cancerdrug resistance |
| spellingShingle | Crescenzo Massaro Elham Safadeh Giulia Sgueglia Hendrik G. Stunnenberg Lucia Altucci Carmela Dell’Aversana MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance Cells microRNA hormone signaling colorectal cancer drug resistance |
| title | MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance |
| title_full | MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance |
| title_fullStr | MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance |
| title_full_unstemmed | MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance |
| title_short | MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance |
| title_sort | microrna assisted hormone cell signaling in colorectal cancer resistance |
| topic | microRNA hormone signaling colorectal cancer drug resistance |
| url | https://www.mdpi.com/2073-4409/10/1/39 |
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