Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives
Genetic editing technologies have emerged as a potential therapeutic tool in various biomedical fields owing to their applications against cancer, neurological diseases, diabetes, autoimmune disorder, muscular dystrophy, bacterial infections (AMR), and cardiovascular diseases. CRISPR is one such val...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522010383 |
| _version_ | 1798006948535205888 |
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| author | Rahul Bhattacharjee Ankit Jana Aditya Nandi Adrija Sinha Arkadyuti Bhattacharjee Sagnik Mitra Sulagna Kar Abhijit Dey Sushil Kumar Singh Rajender S. Varma Pritam Kumar Panda Mrutyunjay Suar Suresh K. Verma |
| author_facet | Rahul Bhattacharjee Ankit Jana Aditya Nandi Adrija Sinha Arkadyuti Bhattacharjee Sagnik Mitra Sulagna Kar Abhijit Dey Sushil Kumar Singh Rajender S. Varma Pritam Kumar Panda Mrutyunjay Suar Suresh K. Verma |
| author_sort | Rahul Bhattacharjee |
| collection | DOAJ |
| description | Genetic editing technologies have emerged as a potential therapeutic tool in various biomedical fields owing to their applications against cancer, neurological diseases, diabetes, autoimmune disorder, muscular dystrophy, bacterial infections (AMR), and cardiovascular diseases. CRISPR is one such valuable genetic editing tool with extensive therapeutic appliances but with a major challenge in terms of delivery. Herein, we have strived to exploit a synergy of nanocarriers and CRISPR against the aforementioned diseases for their medical applications and explicated their clinical significance including the enhanced delivery via endosomal escape and environmental factors such as light, pH, and stimuli. In addition to highlighting the delivery strategies of nano-carriers for CRISPR and their characterization, we have expounded on the reliant factor of the CRISPR-Cas Complex. |
| first_indexed | 2024-04-11T13:02:34Z |
| format | Article |
| id | doaj.art-429f7115849f45da982961a1ab1ca2af |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-11T13:02:34Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-429f7115849f45da982961a1ab1ca2af2022-12-22T04:22:52ZengElsevierMaterials & Design0264-12752022-12-01224111415Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectivesRahul Bhattacharjee0Ankit Jana1Aditya Nandi2Adrija Sinha3Arkadyuti Bhattacharjee4Sagnik Mitra5Sulagna Kar6Abhijit Dey7Sushil Kumar Singh8Rajender S. Varma9Pritam Kumar Panda10Mrutyunjay Suar11Suresh K. Verma12KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, West Bengal, IndiaDBT-NECAB, Department of Agricultural Biotechnology, Assam Agriculture University, Jorhat 785013, Assam, IndiaRegional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic; Corresponding authors at: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India (S.K. Verma).Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden; Corresponding authors at: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India (S.K. Verma).KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India; Corresponding authors at: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India (S.K. Verma).KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India; Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden; Corresponding authors at: KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India (S.K. Verma).Genetic editing technologies have emerged as a potential therapeutic tool in various biomedical fields owing to their applications against cancer, neurological diseases, diabetes, autoimmune disorder, muscular dystrophy, bacterial infections (AMR), and cardiovascular diseases. CRISPR is one such valuable genetic editing tool with extensive therapeutic appliances but with a major challenge in terms of delivery. Herein, we have strived to exploit a synergy of nanocarriers and CRISPR against the aforementioned diseases for their medical applications and explicated their clinical significance including the enhanced delivery via endosomal escape and environmental factors such as light, pH, and stimuli. In addition to highlighting the delivery strategies of nano-carriers for CRISPR and their characterization, we have expounded on the reliant factor of the CRISPR-Cas Complex.http://www.sciencedirect.com/science/article/pii/S0264127522010383NanocarriersCRISPR-Cas complexNon-viral vectorGenome editing |
| spellingShingle | Rahul Bhattacharjee Ankit Jana Aditya Nandi Adrija Sinha Arkadyuti Bhattacharjee Sagnik Mitra Sulagna Kar Abhijit Dey Sushil Kumar Singh Rajender S. Varma Pritam Kumar Panda Mrutyunjay Suar Suresh K. Verma Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives Materials & Design Nanocarriers CRISPR-Cas complex Non-viral vector Genome editing |
| title | Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives |
| title_full | Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives |
| title_fullStr | Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives |
| title_full_unstemmed | Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives |
| title_short | Synergy of nanocarriers with CRISPR-Cas9 in an emerging technology platform for biomedical appliances: Current insights and perspectives |
| title_sort | synergy of nanocarriers with crispr cas9 in an emerging technology platform for biomedical appliances current insights and perspectives |
| topic | Nanocarriers CRISPR-Cas complex Non-viral vector Genome editing |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522010383 |
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