Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats
Objective: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity.Materials and Methods: The groups are included normal (1 ml of corn oil), TAC (2 mg/kg), and co-treatment of PSO (0.4...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-07-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_19703_40ee09098e72a2645805033b3f46eb93.pdf |
| _version_ | 1818204392080277504 |
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| author | Azar Hosseini Arezoo Rajabian Fatemeh Forouzanfar Mahdi Farzadnia Mohammad Taher Boroushaki |
| author_facet | Azar Hosseini Arezoo Rajabian Fatemeh Forouzanfar Mahdi Farzadnia Mohammad Taher Boroushaki |
| author_sort | Azar Hosseini |
| collection | DOAJ |
| description | Objective: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity.Materials and Methods: The groups are included normal (1 ml of corn oil), TAC (2 mg/kg), and co-treatment of PSO (0.4 and 0.8 ml/kg) and TAC. All administrations were carried out intraperitoneally for 14 days. After the last injection, blood was collected from the heart.Results: TAC increased creatinine and urea. Increased malondialdehyde, reduced thiol content and superoxide dismutase. The elevation of lactate dehydrogenase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine kinase-MB and creatinine phosphokinase that confirmed cardiac toxicity. PSO reduced TAC toxicity. PSO decreased TAC-induced pathology injury.Conclusion: PSO reduced TAC toxicity in renal and heart via scavenging free radicals. |
| first_indexed | 2024-12-12T03:40:30Z |
| format | Article |
| id | doaj.art-42a0ff28b8224f049d83db4b979eee92 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-12T03:40:30Z |
| publishDate | 2022-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-42a0ff28b8224f049d83db4b979eee922022-12-22T00:39:42ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492022-07-0112443944810.22038/ajp.2022.1970319703Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in ratsAzar Hosseini0Arezoo Rajabian1Fatemeh Forouzanfar2Mahdi Farzadnia3Mohammad Taher Boroushaki4Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCancer Molecular Pathology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranObjective: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity.Materials and Methods: The groups are included normal (1 ml of corn oil), TAC (2 mg/kg), and co-treatment of PSO (0.4 and 0.8 ml/kg) and TAC. All administrations were carried out intraperitoneally for 14 days. After the last injection, blood was collected from the heart.Results: TAC increased creatinine and urea. Increased malondialdehyde, reduced thiol content and superoxide dismutase. The elevation of lactate dehydrogenase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine kinase-MB and creatinine phosphokinase that confirmed cardiac toxicity. PSO reduced TAC toxicity. PSO decreased TAC-induced pathology injury.Conclusion: PSO reduced TAC toxicity in renal and heart via scavenging free radicals.https://ajp.mums.ac.ir/article_19703_40ee09098e72a2645805033b3f46eb93.pdfpomegranate seed oiltacrolimusnephrotoxicitycardiotoxicity |
| spellingShingle | Azar Hosseini Arezoo Rajabian Fatemeh Forouzanfar Mahdi Farzadnia Mohammad Taher Boroushaki Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats Avicenna Journal of Phytomedicine pomegranate seed oil tacrolimus nephrotoxicity cardiotoxicity |
| title | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
| title_full | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
| title_fullStr | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
| title_full_unstemmed | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
| title_short | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
| title_sort | pomegranate seed oil protects against tacrolimus induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
| topic | pomegranate seed oil tacrolimus nephrotoxicity cardiotoxicity |
| url | https://ajp.mums.ac.ir/article_19703_40ee09098e72a2645805033b3f46eb93.pdf |
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