Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study
Although many genome-wide association studies (GWASs) have evaluated the association with metabolic disorders, the current study is the first attempt to analyze the genetic risk factors for various metabolic disorders according to sex and age groups of the life course in Korean adults. A total popul...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/19/11889 |
| _version_ | 1797478827543232512 |
|---|---|
| author | Young-Sang Kim Yon Chul Park Ja-Eun Choi Jae-Min Park Kunhee Han Kwangyoon Kim Bom-Taeck Kim Kyung-Won Hong |
| author_facet | Young-Sang Kim Yon Chul Park Ja-Eun Choi Jae-Min Park Kunhee Han Kwangyoon Kim Bom-Taeck Kim Kyung-Won Hong |
| author_sort | Young-Sang Kim |
| collection | DOAJ |
| description | Although many genome-wide association studies (GWASs) have evaluated the association with metabolic disorders, the current study is the first attempt to analyze the genetic risk factors for various metabolic disorders according to sex and age groups of the life course in Korean adults. A total population of 50,808 people were included in this GWAS. The genetic traits for eight metabolic phenotypes were investigated in peri-, and postmenopausal women compared to a younger group or men of corresponding age groups. The metabolic phenotypes include general obesity, abdominal obesity, hypertension, type 2 diabetes, hypercholesterolemia, hypertriglyceridemia, hypo-high-density lipoprotein cholesterolemia, and metabolic syndrome. In the total participants, GWAS results for eight metabolic phenotypes found 101 significant loci. Of these, 15 loci were the first reported to be associated with the risk of metabolic disorder. Interestingly, some of the significant loci presented the association with the various phenotypes, which presented when there was a correlation between phenotypes. In addition, we analyzed divided by gender and age (young adult, peri-menopausal group, older adult), and specifically identified specific loci in peri-menopausal women. Meanwhile, several genetic factors associated with metabolic disorders were newly reported in our study. In particular, several genes were significantly associated with one of the metabolic phenotypes in only a single specific group. These findings suggest that menopausal transition rather than aging itself potentiates the influence of genetic risks on metabolic disorders. In addition, some genetic loci with low frequencies may play a role in the metabolic disturbances in a specific sex and age group. The genetic traits derived from our study may contribute to understanding the genetic risk factors for metabolic disorders in the Korean population. |
| first_indexed | 2024-03-09T21:37:08Z |
| format | Article |
| id | doaj.art-42a4dad44bb0404ca3abf7cdbd554f17 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:37:08Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-42a4dad44bb0404ca3abf7cdbd554f172023-11-23T20:40:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191188910.3390/ijms231911889Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology StudyYoung-Sang Kim0Yon Chul Park1Ja-Eun Choi2Jae-Min Park3Kunhee Han4Kwangyoon Kim5Bom-Taeck Kim6Kyung-Won Hong7Department of Family Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, KoreaDepartment of Family Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju-si 26426, KoreaDepartment of Healthcare Technology, Theragen Bio Co., Ltd., Pangyoyeok-ro 240, Seongnam-si 13493, KoreaDepartment of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, KoreaDepartment of Family Medicine, Seonam Hospital, Seoul 08049, KoreaDepartment of Family Practice and Community Health, Ajou University Hospital, Suwon-si 16499, KoreaDepartment of Family Practice and Community Health, Ajou University Hospital, Suwon-si 16499, KoreaDepartment of Family Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju-si 26426, KoreaAlthough many genome-wide association studies (GWASs) have evaluated the association with metabolic disorders, the current study is the first attempt to analyze the genetic risk factors for various metabolic disorders according to sex and age groups of the life course in Korean adults. A total population of 50,808 people were included in this GWAS. The genetic traits for eight metabolic phenotypes were investigated in peri-, and postmenopausal women compared to a younger group or men of corresponding age groups. The metabolic phenotypes include general obesity, abdominal obesity, hypertension, type 2 diabetes, hypercholesterolemia, hypertriglyceridemia, hypo-high-density lipoprotein cholesterolemia, and metabolic syndrome. In the total participants, GWAS results for eight metabolic phenotypes found 101 significant loci. Of these, 15 loci were the first reported to be associated with the risk of metabolic disorder. Interestingly, some of the significant loci presented the association with the various phenotypes, which presented when there was a correlation between phenotypes. In addition, we analyzed divided by gender and age (young adult, peri-menopausal group, older adult), and specifically identified specific loci in peri-menopausal women. Meanwhile, several genetic factors associated with metabolic disorders were newly reported in our study. In particular, several genes were significantly associated with one of the metabolic phenotypes in only a single specific group. These findings suggest that menopausal transition rather than aging itself potentiates the influence of genetic risks on metabolic disorders. In addition, some genetic loci with low frequencies may play a role in the metabolic disturbances in a specific sex and age group. The genetic traits derived from our study may contribute to understanding the genetic risk factors for metabolic disorders in the Korean population.https://www.mdpi.com/1422-0067/23/19/11889premenopauseperimenopausepostmenopausemetabolic disordersgenome-wide association studies |
| spellingShingle | Young-Sang Kim Yon Chul Park Ja-Eun Choi Jae-Min Park Kunhee Han Kwangyoon Kim Bom-Taeck Kim Kyung-Won Hong Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study International Journal of Molecular Sciences premenopause perimenopause postmenopause metabolic disorders genome-wide association studies |
| title | Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study |
| title_full | Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study |
| title_fullStr | Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study |
| title_full_unstemmed | Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study |
| title_short | Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study |
| title_sort | lifestage sex specific genetic effects on metabolic disorders in an adult population in korea the korean genome and epidemiology study |
| topic | premenopause perimenopause postmenopause metabolic disorders genome-wide association studies |
| url | https://www.mdpi.com/1422-0067/23/19/11889 |
| work_keys_str_mv | AT youngsangkim lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy AT yonchulpark lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy AT jaeunchoi lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy AT jaeminpark lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy AT kunheehan lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy AT kwangyoonkim lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy AT bomtaeckkim lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy AT kyungwonhong lifestagesexspecificgeneticeffectsonmetabolicdisordersinanadultpopulationinkoreathekoreangenomeandepidemiologystudy |