Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study
Abstract Dyslipidemia is an emerging disease in China, especially in the presence of hypertension and diabetes mellitus. We investigated the association of dyslipidemia with the use of antihypertensive and antidiabetic agents. The study participants (n = 2423) were hypertensive and diabetic patients...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14264 |
| _version_ | 1827778872045731840 |
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| author | Chao‐Ying Miao Xiao‐Fei Ye Wei Zhang Li‐Nong Ji Ji‐Guang Wang for the ATTEND investigators |
| author_facet | Chao‐Ying Miao Xiao‐Fei Ye Wei Zhang Li‐Nong Ji Ji‐Guang Wang for the ATTEND investigators |
| author_sort | Chao‐Ying Miao |
| collection | DOAJ |
| description | Abstract Dyslipidemia is an emerging disease in China, especially in the presence of hypertension and diabetes mellitus. We investigated the association of dyslipidemia with the use of antihypertensive and antidiabetic agents. The study participants (n = 2423) were hypertensive and diabetic patients enrolled in a China nationwide registry. Serum mean ± (SD, except for serum triglycerides, median [interquatile range]) concentrations were 1.38 (0.97‐2.02) mmol/L, 4.85 ± 1.12 mmol/L, 1.30 ± 0.36 mmol/L, and 2.89 ± 0.92 mmol/L for triglycerides and total, high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL) cholesterol, respectively. The prevalence of dyslipidemia was 18.9%, 13.5%, 16.6%, and 37.7% for hypertriglyceridemia (serum triglycerides ≥2.3 mmol/L), hypercholesterolemia (total cholesterol ≥6.2 mmol/L or LDL cholesterol ≥4.1 mmol/L), low HDL cholesterol (HDL cholesterol <1.0 mmol/L), and any of the three lipid disorders, respectively. Treated (n = 1647), compared with untreated hypertensive patients (n = 303), had a significantly (P ≤ .0006) lower serum total, LDL, and HDL cholesterol, but similar serum triglycerides (P = .20). Treated (n = 1325), compared with untreated diabetic patients (n = 238), had a significantly (P ≤ .004) lower serum triglycerides, and total and LDL cholesterol, but similar serum HDL cholesterol (P = .81). After adjustment, the odds ratios (OR) were significant for hypercholesterolemia (OR 0.76, 95% confidence interval [CI] 0.58‐0.997, P = .048) and low HDL cholesterol (OR 1.56, CI 1.19‐2.03, P = .001) in treated versus untreated hypertension, and for low HDL cholesterol (OR 1.50, CI 1.18‐1.89, P = .0008) in treated versus untreated diabetes. In conclusion, the prevalence of dyslipidemia differed between treated and untreated hypertension and diabetes. |
| first_indexed | 2024-03-11T14:42:00Z |
| format | Article |
| id | doaj.art-42a5793163e04114859588ff3961a39c |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:42:00Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-42a5793163e04114859588ff3961a39c2023-10-30T13:30:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-07-012371399140410.1111/jch.14264Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter studyChao‐Ying Miao0Xiao‐Fei Ye1Wei Zhang2Li‐Nong Ji3Ji‐Guang Wang4for the ATTEND investigatorsSchool of Public Health Shanghai Jiao Tong University School of Medicine Shanghai ChinaSchool of Public Health Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Cardiovascular Medicine The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Endocrinology Renmin Hospital Peking University Beijing ChinaDepartment of Cardiovascular Medicine The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Dyslipidemia is an emerging disease in China, especially in the presence of hypertension and diabetes mellitus. We investigated the association of dyslipidemia with the use of antihypertensive and antidiabetic agents. The study participants (n = 2423) were hypertensive and diabetic patients enrolled in a China nationwide registry. Serum mean ± (SD, except for serum triglycerides, median [interquatile range]) concentrations were 1.38 (0.97‐2.02) mmol/L, 4.85 ± 1.12 mmol/L, 1.30 ± 0.36 mmol/L, and 2.89 ± 0.92 mmol/L for triglycerides and total, high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL) cholesterol, respectively. The prevalence of dyslipidemia was 18.9%, 13.5%, 16.6%, and 37.7% for hypertriglyceridemia (serum triglycerides ≥2.3 mmol/L), hypercholesterolemia (total cholesterol ≥6.2 mmol/L or LDL cholesterol ≥4.1 mmol/L), low HDL cholesterol (HDL cholesterol <1.0 mmol/L), and any of the three lipid disorders, respectively. Treated (n = 1647), compared with untreated hypertensive patients (n = 303), had a significantly (P ≤ .0006) lower serum total, LDL, and HDL cholesterol, but similar serum triglycerides (P = .20). Treated (n = 1325), compared with untreated diabetic patients (n = 238), had a significantly (P ≤ .004) lower serum triglycerides, and total and LDL cholesterol, but similar serum HDL cholesterol (P = .81). After adjustment, the odds ratios (OR) were significant for hypercholesterolemia (OR 0.76, 95% confidence interval [CI] 0.58‐0.997, P = .048) and low HDL cholesterol (OR 1.56, CI 1.19‐2.03, P = .001) in treated versus untreated hypertension, and for low HDL cholesterol (OR 1.50, CI 1.18‐1.89, P = .0008) in treated versus untreated diabetes. In conclusion, the prevalence of dyslipidemia differed between treated and untreated hypertension and diabetes.https://doi.org/10.1111/jch.14264cholesteroldiabetes mellitusdyslipidemiahypertensiontreatment |
| spellingShingle | Chao‐Ying Miao Xiao‐Fei Ye Wei Zhang Li‐Nong Ji Ji‐Guang Wang for the ATTEND investigators Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study The Journal of Clinical Hypertension cholesterol diabetes mellitus dyslipidemia hypertension treatment |
| title | Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study |
| title_full | Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study |
| title_fullStr | Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study |
| title_full_unstemmed | Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study |
| title_short | Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study |
| title_sort | association between dyslipidemia and antihypertensive and antidiabetic treatments in a china multicenter study |
| topic | cholesterol diabetes mellitus dyslipidemia hypertension treatment |
| url | https://doi.org/10.1111/jch.14264 |
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