High-Dose Nebulized Colistin Methanesulfonate and the Role in Hospital-Acquired Pneumonia Caused by Gram-Negative Bacteria with Difficult-to-Treat Resistance: A Review

High-Dose Nebulized Colistin Methanesulfonate and the Role in Hospital-Acquired Pneumonia Caused by Gram-Negative Bacteria with Difficult-to-Treat Resistance: A Review

Hospital-acquired pneumonia, including ventilator-associated pneumonia (VAP) due to difficult-to-treat-resistant (DTR) Gram-negative bacteria, contributes significantly to morbidity and mortality in ICUs. In the era of COVID-19, the incidences of secondary nosocomial pneumonia and the demand for inv...

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Bibliographic Details
Main Authors: Ilias Karaiskos, Aikaterini Gkoufa, Elena Polyzou, Georgios Schinas, Zoe Athanassa, Karolina Akinosoglou
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Microorganisms
Subjects:
colistin methanesulfonate
colistin
high-dose nebulized CMS
nebulizers
clinical efficacy
toxicity
Online Access:https://www.mdpi.com/2076-2607/11/6/1459

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