Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature

Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature

Abstract The renal mesenchyme contains heterogeneous cells, including interstitial fibroblasts and pericytes, with key roles in wound healing. Although healing is impaired in aged kidneys, the effect of age and injury on the mesenchyme remains poorly understood. We characterized renal mesenchymal ce...

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Bibliographic Details
Main Authors: Isaac W. Shaw, Eoin D. O'Sullivan, Angela O. Pisco, Gary Borthwick, Kevin M. Gallagher, Bruno Péault, Jeremy Hughes, David A. Ferenbach
Format: Article
Language:English
Published: Oxford University Press 2021-08-01
Series:Stem Cells Translational Medicine
Subjects:
aging
fibrosis
ischemia
kidney
mesenchyme
pericyte
Online Access:https://doi.org/10.1002/sctm.20-0392

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