Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues

Macrophage is located in different tissue to serve diverse functions. Here the authors use mass spectrometry and bulk RNA-sequencing to profile 11 mouse macrophage populations from 8 tissues, and combine their de novo data with public datasets to report an integrated proteomic and transcriptomic lan...

Full description

Bibliographic Details
Main Authors: Jingbo Qie, Yang Liu, Yunzhi Wang, Fan Zhang, Zhaoyu Qin, Sha Tian, Mingwei Liu, Kai Li, Wenhao Shi, Lei Song, Mingjun Sun, Yexin Tong, Ping Hu, Tao Gong, Xiaqiong Wang, Yi Huang, Bolong Lin, Xuesen Zheng, Rongbin Zhou, Jie Lv, Changsheng Du, Yi Wang, Jun Qin, Wenjun Yang, Fuchu He, Chen Ding
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35095-7
_version_ 1811207655292665856
author Jingbo Qie
Yang Liu
Yunzhi Wang
Fan Zhang
Zhaoyu Qin
Sha Tian
Mingwei Liu
Kai Li
Wenhao Shi
Lei Song
Mingjun Sun
Yexin Tong
Ping Hu
Tao Gong
Xiaqiong Wang
Yi Huang
Bolong Lin
Xuesen Zheng
Rongbin Zhou
Jie Lv
Changsheng Du
Yi Wang
Jun Qin
Wenjun Yang
Fuchu He
Chen Ding
author_facet Jingbo Qie
Yang Liu
Yunzhi Wang
Fan Zhang
Zhaoyu Qin
Sha Tian
Mingwei Liu
Kai Li
Wenhao Shi
Lei Song
Mingjun Sun
Yexin Tong
Ping Hu
Tao Gong
Xiaqiong Wang
Yi Huang
Bolong Lin
Xuesen Zheng
Rongbin Zhou
Jie Lv
Changsheng Du
Yi Wang
Jun Qin
Wenjun Yang
Fuchu He
Chen Ding
author_sort Jingbo Qie
collection DOAJ
description Macrophage is located in different tissue to serve diverse functions. Here the authors use mass spectrometry and bulk RNA-sequencing to profile 11 mouse macrophage populations from 8 tissues, and combine their de novo data with public datasets to report an integrated proteomic and transcriptomic landscape of mouse macrophage as a valuable resource.
first_indexed 2024-04-12T04:08:23Z
format Article
id doaj.art-42aa5c3f294d4fc78c544a437d316019
institution Directory Open Access Journal
issn 2041-1723
language English
last_indexed 2024-04-12T04:08:23Z
publishDate 2022-11-01
publisher Nature Portfolio
record_format Article
series Nature Communications
spelling doaj.art-42aa5c3f294d4fc78c544a437d3160192022-12-22T03:48:34ZengNature PortfolioNature Communications2041-17232022-11-0113112310.1038/s41467-022-35095-7Integrated proteomic and transcriptomic landscape of macrophages in mouse tissuesJingbo Qie0Yang Liu1Yunzhi Wang2Fan Zhang3Zhaoyu Qin4Sha Tian5Mingwei Liu6Kai Li7Wenhao Shi8Lei Song9Mingjun Sun10Yexin Tong11Ping Hu12Tao Gong13Xiaqiong Wang14Yi Huang15Bolong Lin16Xuesen Zheng17Rongbin Zhou18Jie Lv19Changsheng Du20Yi Wang21Jun Qin22Wenjun Yang23Fuchu He24Chen Ding25State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein SciencesState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein SciencesState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein SciencesState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein SciencesState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityDepartment of Pediatric Orthopedics, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of MedicineHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of ChinaPutuo District People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji UniversityPutuo District People’s Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji UniversityState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein SciencesState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityDepartment of Pediatric Orthopedics, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of MedicineState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan UniversityMacrophage is located in different tissue to serve diverse functions. Here the authors use mass spectrometry and bulk RNA-sequencing to profile 11 mouse macrophage populations from 8 tissues, and combine their de novo data with public datasets to report an integrated proteomic and transcriptomic landscape of mouse macrophage as a valuable resource.https://doi.org/10.1038/s41467-022-35095-7
spellingShingle Jingbo Qie
Yang Liu
Yunzhi Wang
Fan Zhang
Zhaoyu Qin
Sha Tian
Mingwei Liu
Kai Li
Wenhao Shi
Lei Song
Mingjun Sun
Yexin Tong
Ping Hu
Tao Gong
Xiaqiong Wang
Yi Huang
Bolong Lin
Xuesen Zheng
Rongbin Zhou
Jie Lv
Changsheng Du
Yi Wang
Jun Qin
Wenjun Yang
Fuchu He
Chen Ding
Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
Nature Communications
title Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
title_full Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
title_fullStr Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
title_full_unstemmed Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
title_short Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
title_sort integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
url https://doi.org/10.1038/s41467-022-35095-7
work_keys_str_mv AT jingboqie integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT yangliu integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT yunzhiwang integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT fanzhang integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT zhaoyuqin integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT shatian integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT mingweiliu integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT kaili integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT wenhaoshi integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT leisong integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT mingjunsun integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT yexintong integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT pinghu integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT taogong integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT xiaqiongwang integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT yihuang integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT bolonglin integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT xuesenzheng integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT rongbinzhou integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT jielv integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT changshengdu integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT yiwang integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT junqin integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT wenjunyang integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT fuchuhe integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues
AT chending integratedproteomicandtranscriptomiclandscapeofmacrophagesinmousetissues