Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects.
After recovery from COVID-19, there is data to suggest potential long-term pulmonary sequelae and associated impairment of functional capacity. This cross-sectional study was designed to assess the impact on respiratory function in a cohort of Indian subjects. Subjects who had recovered from COVID-1...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002884&type=printable |
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| author | Devasahayam Jesudas Christopher Barney T J Isaac Flavita Benna John Deepa Shankar Prasanna Samuel Richa Gupta Balamugesh Thangakunam |
| author_facet | Devasahayam Jesudas Christopher Barney T J Isaac Flavita Benna John Deepa Shankar Prasanna Samuel Richa Gupta Balamugesh Thangakunam |
| author_sort | Devasahayam Jesudas Christopher |
| collection | DOAJ |
| description | After recovery from COVID-19, there is data to suggest potential long-term pulmonary sequelae and associated impairment of functional capacity. This cross-sectional study was designed to assess the impact on respiratory function in a cohort of Indian subjects. Subjects who had recovered from COVID-19 were recruited. Clinical symptoms, pulmonary function test results, 6-minute walk test (6MWT) results, St George's Respiratory questionnaire (SGRQ) and chest radiographs were obtained. Information on the COVID-19 illness during hospitalization, baseline laboratory biomarkers and the disease severity categories as outlined by WHO (asymptomatic, mild, moderate, severe and critical), were retrieved from the hospital records. The 'COVID pneumonia'(WHO category moderate, severe & critical) group was compared with the 'Mild COVID' (WHO category mild) group and likewise, the WHO category moderate and the WHO category severe/critical groups were compared. In 207 subjects, whose mean age was 48.7 years were assessed after an average of 63 days from onset of symptom, 35% had TLC< 80% (restrictive defect), 8.3% had FEV1/FVC<70% (obstructive defect) and 44.4% had diminished DLCO<80% (diffusing capacity). The 'COVID-19 pneumonia' group when compared to the 'mild COVID-19' group, had lower FVC% (77.85 VS 88.18; P = 0.001), TLC% (79.48 VS 87.91; P = 0.0002), DLCO% (75.30 VS 89.20; P<0.0001) and DLCO/VA% (105.6 VS 111.8; P = 0.032), decreased minimum oxygen saturation (94.89 VS 97.73; P<0.0001) and more subjects had a drop in saturation of ≥ 4% (21.69% VS 4.84%; P = 0.001) during the 6MWT, and a greater mean total SGRQ score (29.2 VS 11.0; P<0.0001). To our knowledge, this is the first such report on Indian subjects. We have shown that post-COVID-19 lung damage leads to significant impairment of lung function, quality of life and effort tolerance. |
| first_indexed | 2024-03-08T05:30:45Z |
| format | Article |
| id | doaj.art-42abb48efba146a286c24a02713d88c6 |
| institution | Directory Open Access Journal |
| issn | 2767-3375 |
| language | English |
| last_indexed | 2024-03-08T05:30:45Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj.art-42abb48efba146a286c24a02713d88c62024-02-06T05:56:19ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752024-01-0142e000288410.1371/journal.pgph.0002884Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects.Devasahayam Jesudas ChristopherBarney T J IsaacFlavita Benna JohnDeepa ShankarPrasanna SamuelRicha GuptaBalamugesh ThangakunamAfter recovery from COVID-19, there is data to suggest potential long-term pulmonary sequelae and associated impairment of functional capacity. This cross-sectional study was designed to assess the impact on respiratory function in a cohort of Indian subjects. Subjects who had recovered from COVID-19 were recruited. Clinical symptoms, pulmonary function test results, 6-minute walk test (6MWT) results, St George's Respiratory questionnaire (SGRQ) and chest radiographs were obtained. Information on the COVID-19 illness during hospitalization, baseline laboratory biomarkers and the disease severity categories as outlined by WHO (asymptomatic, mild, moderate, severe and critical), were retrieved from the hospital records. The 'COVID pneumonia'(WHO category moderate, severe & critical) group was compared with the 'Mild COVID' (WHO category mild) group and likewise, the WHO category moderate and the WHO category severe/critical groups were compared. In 207 subjects, whose mean age was 48.7 years were assessed after an average of 63 days from onset of symptom, 35% had TLC< 80% (restrictive defect), 8.3% had FEV1/FVC<70% (obstructive defect) and 44.4% had diminished DLCO<80% (diffusing capacity). The 'COVID-19 pneumonia' group when compared to the 'mild COVID-19' group, had lower FVC% (77.85 VS 88.18; P = 0.001), TLC% (79.48 VS 87.91; P = 0.0002), DLCO% (75.30 VS 89.20; P<0.0001) and DLCO/VA% (105.6 VS 111.8; P = 0.032), decreased minimum oxygen saturation (94.89 VS 97.73; P<0.0001) and more subjects had a drop in saturation of ≥ 4% (21.69% VS 4.84%; P = 0.001) during the 6MWT, and a greater mean total SGRQ score (29.2 VS 11.0; P<0.0001). To our knowledge, this is the first such report on Indian subjects. We have shown that post-COVID-19 lung damage leads to significant impairment of lung function, quality of life and effort tolerance.https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002884&type=printable |
| spellingShingle | Devasahayam Jesudas Christopher Barney T J Isaac Flavita Benna John Deepa Shankar Prasanna Samuel Richa Gupta Balamugesh Thangakunam Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects. PLOS Global Public Health |
| title | Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects. |
| title_full | Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects. |
| title_fullStr | Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects. |
| title_full_unstemmed | Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects. |
| title_short | Impact of post-COVID-19 lung damage on pulmonary function, exercise tolerance and quality of life in Indian subjects. |
| title_sort | impact of post covid 19 lung damage on pulmonary function exercise tolerance and quality of life in indian subjects |
| url | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0002884&type=printable |
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