The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway

The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway

Abstract Background Glioma is the most common and malignant tumor of central nervous system. The tumor initiation, self-renewal, and multi-lineage differentiation abilities of glioma stem cells (GSCs) are responsible for glioma proliferation and recurrence. Although circular RNAs (circRNAs) play vit...

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Bibliographic Details
Main Authors: Junshuang Zhao, Yang Jiang, Haiying Zhang, Jinpeng Zhou, Lian Chen, Hao Li, Jinkun Xu, Guoqing Zhang, Zhitao Jing
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma stem cells
CircATP5B
MiR-185-5P
HOXB5
SRSF1
IL6
Online Access:https://doi.org/10.1186/s13046-021-01931-9

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