Interactions Among Non-Coding RNAs in Diabetic Nephropathy
Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potenti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.00191/full |
| _version_ | 1818174952453439488 |
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| author | Tamil Selvi Loganathan Siti Aishah Sulaiman Nor Azian Abdul Murad Shamsul Azhar Shah Abdul Halim Abdul Gafor Rahman Jamal Noraidatulakma Abdullah |
| author_facet | Tamil Selvi Loganathan Siti Aishah Sulaiman Nor Azian Abdul Murad Shamsul Azhar Shah Abdul Halim Abdul Gafor Rahman Jamal Noraidatulakma Abdullah |
| author_sort | Tamil Selvi Loganathan |
| collection | DOAJ |
| description | Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potentially can be used as biomarkers and therapeutic targets. NcRNAs refers to the RNA species that do not encode for any protein, and the most known ncRNAs are the microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Dysregulation of these ncRNAs was reported before in DN patients and animal models of DN. Importantly, there are some interactions between these ncRNAs to regulate the crucial steps in DN progression. Here, we aimed to discuss the reported ncRNAs in DN and their interactions with critical genes in DN progression. Elucidating these ncRNAs regulatory network will allow for a better understanding of the molecular mechanisms in DN and how they can act as new biomarkers for DN and also as the potential targets for treatment. |
| first_indexed | 2024-12-11T19:52:34Z |
| format | Article |
| id | doaj.art-42ae30b5c9054ef18d5003dc4aadbfec |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T19:52:34Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-42ae30b5c9054ef18d5003dc4aadbfec2022-12-22T00:52:44ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-03-011110.3389/fphar.2020.00191489228Interactions Among Non-Coding RNAs in Diabetic NephropathyTamil Selvi Loganathan0Siti Aishah Sulaiman1Nor Azian Abdul Murad2Shamsul Azhar Shah3Abdul Halim Abdul Gafor4Rahman Jamal5Noraidatulakma Abdullah6UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaUKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaUKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDepartment of Community Health, UKM Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaNephrology Unit, Faculty of Medicine, UKM Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaUKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaUKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaDiabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potentially can be used as biomarkers and therapeutic targets. NcRNAs refers to the RNA species that do not encode for any protein, and the most known ncRNAs are the microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Dysregulation of these ncRNAs was reported before in DN patients and animal models of DN. Importantly, there are some interactions between these ncRNAs to regulate the crucial steps in DN progression. Here, we aimed to discuss the reported ncRNAs in DN and their interactions with critical genes in DN progression. Elucidating these ncRNAs regulatory network will allow for a better understanding of the molecular mechanisms in DN and how they can act as new biomarkers for DN and also as the potential targets for treatment.https://www.frontiersin.org/article/10.3389/fphar.2020.00191/fulllncRNAmiRNAcircRNAdiabetic nephropathybiomarkerskidney disease |
| spellingShingle | Tamil Selvi Loganathan Siti Aishah Sulaiman Nor Azian Abdul Murad Shamsul Azhar Shah Abdul Halim Abdul Gafor Rahman Jamal Noraidatulakma Abdullah Interactions Among Non-Coding RNAs in Diabetic Nephropathy Frontiers in Pharmacology lncRNA miRNA circRNA diabetic nephropathy biomarkers kidney disease |
| title | Interactions Among Non-Coding RNAs in Diabetic Nephropathy |
| title_full | Interactions Among Non-Coding RNAs in Diabetic Nephropathy |
| title_fullStr | Interactions Among Non-Coding RNAs in Diabetic Nephropathy |
| title_full_unstemmed | Interactions Among Non-Coding RNAs in Diabetic Nephropathy |
| title_short | Interactions Among Non-Coding RNAs in Diabetic Nephropathy |
| title_sort | interactions among non coding rnas in diabetic nephropathy |
| topic | lncRNA miRNA circRNA diabetic nephropathy biomarkers kidney disease |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.00191/full |
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