Silk Fibroin-Based Biomaterials for Hemostatic Applications
Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent at the right time, they must understand the mechan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/5/660 |
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| author | Md. Tipu Sultan Heesun Hong Ok Joo Lee Olatunji Ajiteru Young Jin Lee Ji Seung Lee Hanna Lee Soon Hee Kim Chan Hum Park |
| author_facet | Md. Tipu Sultan Heesun Hong Ok Joo Lee Olatunji Ajiteru Young Jin Lee Ji Seung Lee Hanna Lee Soon Hee Kim Chan Hum Park |
| author_sort | Md. Tipu Sultan |
| collection | DOAJ |
| description | Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent at the right time, they must understand the mechanisms of action, the effectiveness, and the possible adverse effects of each agent. Over the past decade, various hemostatic agents have grown intensely. These agents vary from absorbable topical hemostats, including collagen, gelatins, microfibrillar, and regenerated oxidized cellulose, to biologically active topical hemostats such as thrombin, biological adhesives, and other combined agents. Commercially available products have since expanded to include topical hemostats, surgical sealants, and adhesives. Silk is a natural protein consisting of fibroin and sericin. Silk fibroin (SF), derived from silkworm <i>Bombyx mori</i>, is a fibrous protein that has been used mostly in fashion textiles and surgical sutures. Additionally, SF has been widely applied as a potential biomaterial in several biomedical and biotechnological fields. Furthermore, SF has been employed as a hemostatic agent in several studies. In this review, we summarize the several morphologic forms of SF and the latest technological advances on the use of SF-based hemostatic agents. |
| first_indexed | 2024-03-10T03:15:23Z |
| format | Article |
| id | doaj.art-42b037a8dabc438a8bfff5eef4a85f7e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T03:15:23Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-42b037a8dabc438a8bfff5eef4a85f7e2023-11-23T10:13:42ZengMDPI AGBiomolecules2218-273X2022-04-0112566010.3390/biom12050660Silk Fibroin-Based Biomaterials for Hemostatic ApplicationsMd. Tipu Sultan0Heesun Hong1Ok Joo Lee2Olatunji Ajiteru3Young Jin Lee4Ji Seung Lee5Hanna Lee6Soon Hee Kim7Chan Hum Park8Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaNano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, KoreaHemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent at the right time, they must understand the mechanisms of action, the effectiveness, and the possible adverse effects of each agent. Over the past decade, various hemostatic agents have grown intensely. These agents vary from absorbable topical hemostats, including collagen, gelatins, microfibrillar, and regenerated oxidized cellulose, to biologically active topical hemostats such as thrombin, biological adhesives, and other combined agents. Commercially available products have since expanded to include topical hemostats, surgical sealants, and adhesives. Silk is a natural protein consisting of fibroin and sericin. Silk fibroin (SF), derived from silkworm <i>Bombyx mori</i>, is a fibrous protein that has been used mostly in fashion textiles and surgical sutures. Additionally, SF has been widely applied as a potential biomaterial in several biomedical and biotechnological fields. Furthermore, SF has been employed as a hemostatic agent in several studies. In this review, we summarize the several morphologic forms of SF and the latest technological advances on the use of SF-based hemostatic agents.https://www.mdpi.com/2218-273X/12/5/660silk fibroinhemostatic agentpowderspongesealantmedical application |
| spellingShingle | Md. Tipu Sultan Heesun Hong Ok Joo Lee Olatunji Ajiteru Young Jin Lee Ji Seung Lee Hanna Lee Soon Hee Kim Chan Hum Park Silk Fibroin-Based Biomaterials for Hemostatic Applications Biomolecules silk fibroin hemostatic agent powder sponge sealant medical application |
| title | Silk Fibroin-Based Biomaterials for Hemostatic Applications |
| title_full | Silk Fibroin-Based Biomaterials for Hemostatic Applications |
| title_fullStr | Silk Fibroin-Based Biomaterials for Hemostatic Applications |
| title_full_unstemmed | Silk Fibroin-Based Biomaterials for Hemostatic Applications |
| title_short | Silk Fibroin-Based Biomaterials for Hemostatic Applications |
| title_sort | silk fibroin based biomaterials for hemostatic applications |
| topic | silk fibroin hemostatic agent powder sponge sealant medical application |
| url | https://www.mdpi.com/2218-273X/12/5/660 |
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