Evaluation of spleen stiffness in healthy volunteers using point shear wave elastography
Introduction and Objectives: This study aims to measure the values of spleen stiffness (SS) in healthy subjects, the inter-operator agreement in SS measurement, and to detect statistically significant correlations between SS and age, sex, weight, BMI, portal vein dynamics and splenic dimensions. Mat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119300559 |
| _version_ | 1824020734781947904 |
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| author | Mauro Giuffrè Daniele Macor Flora Masutti Cristiana Abazia Fabio Tinè Riccardo Patti Matteo Rossano Buonocore Anna Colombo Alessia Visintin Michele Campigotto Lory Saveria Crocè |
| author_facet | Mauro Giuffrè Daniele Macor Flora Masutti Cristiana Abazia Fabio Tinè Riccardo Patti Matteo Rossano Buonocore Anna Colombo Alessia Visintin Michele Campigotto Lory Saveria Crocè |
| author_sort | Mauro Giuffrè |
| collection | DOAJ |
| description | Introduction and Objectives: This study aims to measure the values of spleen stiffness (SS) in healthy subjects, the inter-operator agreement in SS measurement, and to detect statistically significant correlations between SS and age, sex, weight, BMI, portal vein dynamics and splenic dimensions. Materials and methods: The study included 100 healthy volunteers who had no substantial alcohol intake (<30 g/daily for man, <20 g/daily women), were negative on hepatitis B, hepatitis C, HIV blood serology, and had any history of lymphoproliferative disorders. Abdominal ultrasound, liver and spleen elastography were performed on each patient to search for focal splenic lesions, bile tract or portal vein dilatation, moderate/severe liver steatosis, and to measure liver and spleen stiffness. Results: The mean value was 18.14 (±3.08) kPa. In the group of men (n = 49), the mean was 17.73 (±2.91) kPa, whereas in the group of women (n = 51) it was 16.72 (±3.32) kPa. Statistical analyses showed no correlation between spleen stiffness and sex, age, weight, and BMI. Regarding their splenoportal axis, statistically significant differences in SS were found in the means of the two subgroups of subjects stratified by their portal flow velocity (p = 0.003) and spleen area (p < 0.001).Spearman's rank showed a weak association between SS and portal flow velocty (r = 0.271) and splenic area (r = −0.237). ICC showed excellent (0.96) inter-operator agreement and Bland–Altman plot demonstrated no systematic over/under-estimation of spleen stiffness values. Conclusions: Our results may serve as a reference point in the evaluation of SS especially in patients affected by advanced liver disease. |
| first_indexed | 2024-12-19T01:35:21Z |
| format | Article |
| id | doaj.art-42b12b33cf0740298bb198e58f9a54e4 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-19T01:35:21Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-42b12b33cf0740298bb198e58f9a54e42022-12-21T20:41:57ZengElsevierAnnals of Hepatology1665-26812019-09-01185736741Evaluation of spleen stiffness in healthy volunteers using point shear wave elastographyMauro Giuffrè0Daniele Macor1Flora Masutti2Cristiana Abazia3Fabio Tinè4Riccardo Patti5Matteo Rossano Buonocore6Anna Colombo7Alessia Visintin8Michele Campigotto9Lory Saveria Crocè10Dipartimento Universitario Clinico Di Scienze Mediche Chirurgiche e Della Salute, Università Degli Studi Di Trieste, Italy; Corresponding author at: Via Quinto Baieno, 1, 34127 Trieste, TS, Italy.Dipartimento Universitario Clinico Di Scienze Mediche Chirurgiche e Della Salute, Università Degli Studi Di Trieste, ItalyClinica Patologie Fegato, Azienda Sanitaria Universitaria Integrata Di Trieste, ItalyClinica Patologie Fegato, Azienda Sanitaria Universitaria Integrata Di Trieste, ItalyClinica Patologie Fegato, Azienda Sanitaria Universitaria Integrata Di Trieste, ItalyClinica Patologie Fegato, Azienda Sanitaria Universitaria Integrata Di Trieste, ItalyDipartimento Universitario Clinico Di Scienze Mediche Chirurgiche e Della Salute, Università Degli Studi Di Trieste, ItalyDipartimento Universitario Clinico Di Scienze Mediche Chirurgiche e Della Salute, Università Degli Studi Di Trieste, ItalyDipartimento Universitario Clinico Di Scienze Mediche Chirurgiche e Della Salute, Università Degli Studi Di Trieste, ItalyDipartimento Universitario Clinico Di Scienze Mediche Chirurgiche e Della Salute, Università Degli Studi Di Trieste, ItalyDipartimento Universitario Clinico Di Scienze Mediche Chirurgiche e Della Salute, Università Degli Studi Di Trieste, Italy; Clinica Patologie Fegato, Azienda Sanitaria Universitaria Integrata Di Trieste, Italy; Fondazione Italiana Fegato, ItalyIntroduction and Objectives: This study aims to measure the values of spleen stiffness (SS) in healthy subjects, the inter-operator agreement in SS measurement, and to detect statistically significant correlations between SS and age, sex, weight, BMI, portal vein dynamics and splenic dimensions. Materials and methods: The study included 100 healthy volunteers who had no substantial alcohol intake (<30 g/daily for man, <20 g/daily women), were negative on hepatitis B, hepatitis C, HIV blood serology, and had any history of lymphoproliferative disorders. Abdominal ultrasound, liver and spleen elastography were performed on each patient to search for focal splenic lesions, bile tract or portal vein dilatation, moderate/severe liver steatosis, and to measure liver and spleen stiffness. Results: The mean value was 18.14 (±3.08) kPa. In the group of men (n = 49), the mean was 17.73 (±2.91) kPa, whereas in the group of women (n = 51) it was 16.72 (±3.32) kPa. Statistical analyses showed no correlation between spleen stiffness and sex, age, weight, and BMI. Regarding their splenoportal axis, statistically significant differences in SS were found in the means of the two subgroups of subjects stratified by their portal flow velocity (p = 0.003) and spleen area (p < 0.001).Spearman's rank showed a weak association between SS and portal flow velocty (r = 0.271) and splenic area (r = −0.237). ICC showed excellent (0.96) inter-operator agreement and Bland–Altman plot demonstrated no systematic over/under-estimation of spleen stiffness values. Conclusions: Our results may serve as a reference point in the evaluation of SS especially in patients affected by advanced liver disease.http://www.sciencedirect.com/science/article/pii/S1665268119300559Spleen elastographySpleen stiffnesspSWESpleen stiffness healthy subjectsSpleen |
| spellingShingle | Mauro Giuffrè Daniele Macor Flora Masutti Cristiana Abazia Fabio Tinè Riccardo Patti Matteo Rossano Buonocore Anna Colombo Alessia Visintin Michele Campigotto Lory Saveria Crocè Evaluation of spleen stiffness in healthy volunteers using point shear wave elastography Annals of Hepatology Spleen elastography Spleen stiffness pSWE Spleen stiffness healthy subjects Spleen |
| title | Evaluation of spleen stiffness in healthy volunteers using point shear wave elastography |
| title_full | Evaluation of spleen stiffness in healthy volunteers using point shear wave elastography |
| title_fullStr | Evaluation of spleen stiffness in healthy volunteers using point shear wave elastography |
| title_full_unstemmed | Evaluation of spleen stiffness in healthy volunteers using point shear wave elastography |
| title_short | Evaluation of spleen stiffness in healthy volunteers using point shear wave elastography |
| title_sort | evaluation of spleen stiffness in healthy volunteers using point shear wave elastography |
| topic | Spleen elastography Spleen stiffness pSWE Spleen stiffness healthy subjects Spleen |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119300559 |
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