Experimental Epileptogenesis in a Cell Culture Model of Primary Neurons from Rat Brain: A Temporal Multi-Scale Study

Experimental Epileptogenesis in a Cell Culture Model of Primary Neurons from Rat Brain: A Temporal Multi-Scale Study

Understanding seizure development requires an integrated knowledge of different scales of organization of epileptic networks. We developed a model of “epilepsy-in-a-dish” based on dissociated primary neuronal cells from neonatal rat hippocampus. We demonstrate how a single application of glutamate s...

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Bibliographic Details
Main Authors: Janos Jablonski, Lucas Hoffmann, Ingmar Blümcke, Anna Fejtová, Steffen Uebe, Arif B. Ekici, Vadym Gnatkovsky, Katja Kobow
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
epilepsy
in vitro
epigenetic
DNA methylation
Online Access:https://www.mdpi.com/2073-4409/10/11/3004

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