Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is one of the most frequent pregnancy complications with potential adverse outcomes for mothers and newborns. Its effects on the newborn appear during the neonatal period or early childhood. Therefore, an early diagnosis is crucial to prevent the development of ch...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/11/723 |
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| author | Ana Sofía Herrera-Van Oostdam Mariana Salgado-Bustamante Victoria Lima-Rogel Juan José Oropeza-Valdez Jesús Adrián López Iván Daniel Román Rodríguez Juan Carlos Toro-Ortiz David Alejandro Herrera-Van Oostdam Yamilé López-Hernández Joel Monárrez-Espino |
| author_facet | Ana Sofía Herrera-Van Oostdam Mariana Salgado-Bustamante Victoria Lima-Rogel Juan José Oropeza-Valdez Jesús Adrián López Iván Daniel Román Rodríguez Juan Carlos Toro-Ortiz David Alejandro Herrera-Van Oostdam Yamilé López-Hernández Joel Monárrez-Espino |
| author_sort | Ana Sofía Herrera-Van Oostdam |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is one of the most frequent pregnancy complications with potential adverse outcomes for mothers and newborns. Its effects on the newborn appear during the neonatal period or early childhood. Therefore, an early diagnosis is crucial to prevent the development of chronic diseases later in adult life. In this study, the urinary metabolome of babies born to GDM mothers was characterized. In total, 144 neonatal and maternal (second and third trimesters of pregnancy) urinary samples were analyzed using targeted metabolomics, combining liquid chromatographic mass spectrometry (LC-MS/MS) and flow injection analysis mass spectrometry (FIA-MS/MS) techniques. We provide here the neonatal urinary concentration values of 101 metabolites for 26 newborns born to GDM mothers and 22 newborns born to healthy mothers. The univariate analysis of these metabolites revealed statistical differences in 11 metabolites. Multivariate analyses revealed a differential metabolic profile in newborns of GDM mothers characterized by dysregulation of acylcarnitines, amino acids, and polyamine metabolism. Levels of hexadecenoylcarnitine (C16:1) and spermine were also higher in newborns of GDM mothers. The maternal urinary metabolome revealed significant differences in butyric, isobutyric, and uric acid in the second and third trimesters of pregnancy. These metabolic alterations point to the impact of GDM in the neonatal period. |
| first_indexed | 2024-03-10T05:17:38Z |
| format | Article |
| id | doaj.art-42b25e9e62664e87b609e013a02faf18 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T05:17:38Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-42b25e9e62664e87b609e013a02faf182023-11-23T00:20:36ZengMDPI AGMetabolites2218-19892021-10-01111172310.3390/metabo11110723Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes MellitusAna Sofía Herrera-Van Oostdam0Mariana Salgado-Bustamante1Victoria Lima-Rogel2Juan José Oropeza-Valdez3Jesús Adrián López4Iván Daniel Román Rodríguez5Juan Carlos Toro-Ortiz6David Alejandro Herrera-Van Oostdam7Yamilé López-Hernández8Joel Monárrez-Espino9Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78290, MexicoDepartamento de Bioquímica, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78290, MexicoHospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí 78290, MexicoInstituto Mexicano del Seguro Social, Unidad de Investigación Biomédica de Zacatecas, Zacatecas 98000, MexicoMicroRNAs and Cancer Laboratory, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas 98000, MexicoMetabolomics and Proteomics Laboratory, Universidad Autónoma de Zacatecas, Zacatecas 98000, MexicoHospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí 78290, MexicoHospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí 78290, MexicoMetabolomics and Proteomics Laboratory, Universidad Autónoma de Zacatecas, Zacatecas 98000, MexicoDepartment of Health Research, Christus Muguerza del Parque Hospital Chihuahua, University of Monterrey, San Pedro Garza García, Nuevo León 66238, MexicoGestational diabetes mellitus (GDM) is one of the most frequent pregnancy complications with potential adverse outcomes for mothers and newborns. Its effects on the newborn appear during the neonatal period or early childhood. Therefore, an early diagnosis is crucial to prevent the development of chronic diseases later in adult life. In this study, the urinary metabolome of babies born to GDM mothers was characterized. In total, 144 neonatal and maternal (second and third trimesters of pregnancy) urinary samples were analyzed using targeted metabolomics, combining liquid chromatographic mass spectrometry (LC-MS/MS) and flow injection analysis mass spectrometry (FIA-MS/MS) techniques. We provide here the neonatal urinary concentration values of 101 metabolites for 26 newborns born to GDM mothers and 22 newborns born to healthy mothers. The univariate analysis of these metabolites revealed statistical differences in 11 metabolites. Multivariate analyses revealed a differential metabolic profile in newborns of GDM mothers characterized by dysregulation of acylcarnitines, amino acids, and polyamine metabolism. Levels of hexadecenoylcarnitine (C16:1) and spermine were also higher in newborns of GDM mothers. The maternal urinary metabolome revealed significant differences in butyric, isobutyric, and uric acid in the second and third trimesters of pregnancy. These metabolic alterations point to the impact of GDM in the neonatal period.https://www.mdpi.com/2218-1989/11/11/723newbornsmetabolomicsgestational diabetespregnancy |
| spellingShingle | Ana Sofía Herrera-Van Oostdam Mariana Salgado-Bustamante Victoria Lima-Rogel Juan José Oropeza-Valdez Jesús Adrián López Iván Daniel Román Rodríguez Juan Carlos Toro-Ortiz David Alejandro Herrera-Van Oostdam Yamilé López-Hernández Joel Monárrez-Espino Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus Metabolites newborns metabolomics gestational diabetes pregnancy |
| title | Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus |
| title_full | Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus |
| title_fullStr | Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus |
| title_full_unstemmed | Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus |
| title_short | Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus |
| title_sort | urinary metabolomic profile of neonates born to women with gestational diabetes mellitus |
| topic | newborns metabolomics gestational diabetes pregnancy |
| url | https://www.mdpi.com/2218-1989/11/11/723 |
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