Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors
<p>Abstract</p> <p>Background</p> <p>Although intra-articular hyaluronic acid is well established as a treatment for osteoarthritis of the knee, its use in hip osteoarthritis is not based on large randomized controlled trials. There is a need for more rigorously designe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-11-01
|
| Series: | BMC Musculoskeletal Disorders |
| Online Access: | http://www.biomedcentral.com/1471-2474/11/264 |
| _version_ | 1818021105032495104 |
|---|---|
| author | Bellemans Johan van den Bekerom Michel PJ Colen Sascha Mulier Michiel |
| author_facet | Bellemans Johan van den Bekerom Michel PJ Colen Sascha Mulier Michiel |
| author_sort | Bellemans Johan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Although intra-articular hyaluronic acid is well established as a treatment for osteoarthritis of the knee, its use in hip osteoarthritis is not based on large randomized controlled trials. There is a need for more rigorously designed studies on hip osteoarthritis treatment as this subject is still very much under debate.</p> <p>Methods/Design</p> <p>Randomized, controlled trial with a three-armed, parallel-group design. Approximately 315 patients complying with the inclusion and exclusion criteria will be randomized into one of the following treatment groups: infiltration of the hip joint with hyaluronic acid, with a corticosteroid or with 0.125% bupivacaine.</p> <p>The following outcome measure instruments will be assessed at baseline, i.e. before the intra-articular injection of one of the study products, and then again at six weeks, 3 and 6 months after the initial injection: Pain (100 mm VAS), Harris Hip Score and HOOS, patient assessment of their clinical status (worse, stable or better then at the time of enrollment) and intake of pain rescue medication (number per week). In addition patients will be asked if they have complications/adverse events. The six-month follow-up period for all patients will begin on the date the first injection is administered.</p> <p>Discussion</p> <p>This randomized, controlled, three-arm study will hopefully provide robust information on two of the intra-articular treatments used in hip osteoarthritis, in comparison to bupivacaine.</p> <p>Trial registration</p> <p>NCT01079455</p> |
| first_indexed | 2024-04-14T08:14:20Z |
| format | Article |
| id | doaj.art-42b3f7d117b449e09009af1b090f7da9 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-14T08:14:20Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-42b3f7d117b449e09009af1b090f7da92022-12-22T02:04:27ZengBMCBMC Musculoskeletal Disorders1471-24742010-11-0111126410.1186/1471-2474-11-264Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessorsBellemans Johanvan den Bekerom Michel PJColen SaschaMulier Michiel<p>Abstract</p> <p>Background</p> <p>Although intra-articular hyaluronic acid is well established as a treatment for osteoarthritis of the knee, its use in hip osteoarthritis is not based on large randomized controlled trials. There is a need for more rigorously designed studies on hip osteoarthritis treatment as this subject is still very much under debate.</p> <p>Methods/Design</p> <p>Randomized, controlled trial with a three-armed, parallel-group design. Approximately 315 patients complying with the inclusion and exclusion criteria will be randomized into one of the following treatment groups: infiltration of the hip joint with hyaluronic acid, with a corticosteroid or with 0.125% bupivacaine.</p> <p>The following outcome measure instruments will be assessed at baseline, i.e. before the intra-articular injection of one of the study products, and then again at six weeks, 3 and 6 months after the initial injection: Pain (100 mm VAS), Harris Hip Score and HOOS, patient assessment of their clinical status (worse, stable or better then at the time of enrollment) and intake of pain rescue medication (number per week). In addition patients will be asked if they have complications/adverse events. The six-month follow-up period for all patients will begin on the date the first injection is administered.</p> <p>Discussion</p> <p>This randomized, controlled, three-arm study will hopefully provide robust information on two of the intra-articular treatments used in hip osteoarthritis, in comparison to bupivacaine.</p> <p>Trial registration</p> <p>NCT01079455</p>http://www.biomedcentral.com/1471-2474/11/264 |
| spellingShingle | Bellemans Johan van den Bekerom Michel PJ Colen Sascha Mulier Michiel Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors BMC Musculoskeletal Disorders |
| title | Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors |
| title_full | Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors |
| title_fullStr | Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors |
| title_full_unstemmed | Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors |
| title_short | Comparison of intra-articular injections of Hyaluronic Acid and Corticosteroid in the treatment of Osteoarthritis of the hip in comparison with intra-articular injections of Bupivacaine. Design of a prospective, randomized, controlled study with blinding of the patients and outcome assessors |
| title_sort | comparison of intra articular injections of hyaluronic acid and corticosteroid in the treatment of osteoarthritis of the hip in comparison with intra articular injections of bupivacaine design of a prospective randomized controlled study with blinding of the patients and outcome assessors |
| url | http://www.biomedcentral.com/1471-2474/11/264 |
| work_keys_str_mv | AT bellemansjohan comparisonofintraarticularinjectionsofhyaluronicacidandcorticosteroidinthetreatmentofosteoarthritisofthehipincomparisonwithintraarticularinjectionsofbupivacainedesignofaprospectiverandomizedcontrolledstudywithblindingofthepatientsandoutcomeassessors AT vandenbekerommichelpj comparisonofintraarticularinjectionsofhyaluronicacidandcorticosteroidinthetreatmentofosteoarthritisofthehipincomparisonwithintraarticularinjectionsofbupivacainedesignofaprospectiverandomizedcontrolledstudywithblindingofthepatientsandoutcomeassessors AT colensascha comparisonofintraarticularinjectionsofhyaluronicacidandcorticosteroidinthetreatmentofosteoarthritisofthehipincomparisonwithintraarticularinjectionsofbupivacainedesignofaprospectiverandomizedcontrolledstudywithblindingofthepatientsandoutcomeassessors AT muliermichiel comparisonofintraarticularinjectionsofhyaluronicacidandcorticosteroidinthetreatmentofosteoarthritisofthehipincomparisonwithintraarticularinjectionsofbupivacainedesignofaprospectiverandomizedcontrolledstudywithblindingofthepatientsandoutcomeassessors |