Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer

Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer

Targeting pentose phosphate pathway (PPP) enzymes has emerged as a promising strategy to combat cancer. 6-Phosphogluconate dehydrogenase (6-PGD), the third critical enzyme of the PPP, catalyzes oxidative decarboxylation of 6-phosphogluconate (6-PG) to produce ribulose-5-phosphate (Ru-5-P) and CO2. O...

Full description

Bibliographic Details
Main Authors: Gul Bushra Khan, Muhammad Qasim, Azhar Rasul, Usman Ali Ashfaq, Abdullah M. Alnuqaydan
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Metabolites
Subjects:
in silico
docking
6-PGD
natural inhibitors
enzymatic assay
MD simulation
Online Access:https://www.mdpi.com/2218-1989/13/1/34

Similar Items

Similar Items