Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer

Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer

Targeting pentose phosphate pathway (PPP) enzymes has emerged as a promising strategy to combat cancer. 6-Phosphogluconate dehydrogenase (6-PGD), the third critical enzyme of the PPP, catalyzes oxidative decarboxylation of 6-phosphogluconate (6-PG) to produce ribulose-5-phosphate (Ru-5-P) and CO2. O...

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Bibliographic Details
Main Authors:	Gul Bushra Khan, Muhammad Qasim, Azhar Rasul, Usman Ali Ashfaq, Abdullah M. Alnuqaydan
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Metabolites
Subjects:	in silico docking 6-PGD natural inhibitors enzymatic assay MD simulation
Online Access:	https://www.mdpi.com/2218-1989/13/1/34

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