Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes
In deep brain stimulation (DBS) studies in patients with Parkinson’s disease, the Lead-DBS toolbox allows the reconstruction of the location of β-oscillations in the subthalamic nucleus (STN) using Vercise Cartesia directional electrodes (Boston Scientific). The objective was to compare these probab...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/2306-5354/10/8/898 |
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| author | Colette Boëx Abdullah Al Awadhi Rémi Tyrand Marco V. Corniola Astrid Kibleur Vanessa Fleury Pierre R. Burkhard Shahan Momjian |
| author_facet | Colette Boëx Abdullah Al Awadhi Rémi Tyrand Marco V. Corniola Astrid Kibleur Vanessa Fleury Pierre R. Burkhard Shahan Momjian |
| author_sort | Colette Boëx |
| collection | DOAJ |
| description | In deep brain stimulation (DBS) studies in patients with Parkinson’s disease, the Lead-DBS toolbox allows the reconstruction of the location of β-oscillations in the subthalamic nucleus (STN) using Vercise Cartesia directional electrodes (Boston Scientific). The objective was to compare these probabilistic locations with those of intraoperative monopolar β-oscillations computed from local field potentials (0.5–3 kHz) recorded by using shielded single wires and an extracranial shielded reference electrode. For each electrode contact, power spectral densities of the β-band (13–31 Hz) were compared with those of all eight electrode contacts on the directional electrodes. The DBS Intrinsic Template AtLas (DISTAL), electrophysiological, and DBS target atlases of the Lead-DBS toolbox were applied to the reconstructed electrodes from preoperative MRI and postoperative CT. Thirty-six electrodes (20 patients: 7 females, 13 males; both STN electrodes for 16 of 20 patients; one single STN electrode for 4 of 20 patients) were analyzed. Stimulation sites both dorsal and/or lateral to the sensorimotor STN were the most efficient. In 33 out of 36 electrodes, at least one contact was measured with stronger β-oscillations, including 23 electrodes running through or touching the ventral subpart of the β-oscillations’ probabilistic volume, while 10 did not touch it but were adjacent to this volume; in 3 out of 36 electrodes, no contact was found with β-oscillations and all 3 were distant from this volume. Monopolar local field potentials confirmed the ventral subpart of the probabilistic β-oscillations. |
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| last_indexed | 2024-03-11T00:07:18Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-42b5276e3b724d39a726a0036d6b3b892023-11-19T00:17:34ZengMDPI AGBioengineering2306-53542023-07-0110889810.3390/bioengineering10080898Validation of Lead-DBS β-Oscillation Localization with Directional ElectrodesColette Boëx0Abdullah Al Awadhi1Rémi Tyrand2Marco V. Corniola3Astrid Kibleur4Vanessa Fleury5Pierre R. Burkhard6Shahan Momjian7Department of Neurosurgery, University Hospitals of Geneva, CH-1205 Geneva, SwitzerlandDepartment of Neurosurgery, University Hospitals of Geneva, CH-1205 Geneva, SwitzerlandDepartment of Neurosurgery, University Hospitals of Geneva, CH-1205 Geneva, SwitzerlandDepartment of Neurosurgery, Pontchaillou Hospitals, CEDEX 9, F-35033 Rennes, FranceCentre Hospitalier Universitaire Caen Normandie, F-14000 Caen, FranceFaculty of Medicine, University of Geneva, 1206 Geneva, SwitzerlandFaculty of Medicine, University of Geneva, 1206 Geneva, SwitzerlandDepartment of Neurosurgery, University Hospitals of Geneva, CH-1205 Geneva, SwitzerlandIn deep brain stimulation (DBS) studies in patients with Parkinson’s disease, the Lead-DBS toolbox allows the reconstruction of the location of β-oscillations in the subthalamic nucleus (STN) using Vercise Cartesia directional electrodes (Boston Scientific). The objective was to compare these probabilistic locations with those of intraoperative monopolar β-oscillations computed from local field potentials (0.5–3 kHz) recorded by using shielded single wires and an extracranial shielded reference electrode. For each electrode contact, power spectral densities of the β-band (13–31 Hz) were compared with those of all eight electrode contacts on the directional electrodes. The DBS Intrinsic Template AtLas (DISTAL), electrophysiological, and DBS target atlases of the Lead-DBS toolbox were applied to the reconstructed electrodes from preoperative MRI and postoperative CT. Thirty-six electrodes (20 patients: 7 females, 13 males; both STN electrodes for 16 of 20 patients; one single STN electrode for 4 of 20 patients) were analyzed. Stimulation sites both dorsal and/or lateral to the sensorimotor STN were the most efficient. In 33 out of 36 electrodes, at least one contact was measured with stronger β-oscillations, including 23 electrodes running through or touching the ventral subpart of the β-oscillations’ probabilistic volume, while 10 did not touch it but were adjacent to this volume; in 3 out of 36 electrodes, no contact was found with β-oscillations and all 3 were distant from this volume. Monopolar local field potentials confirmed the ventral subpart of the probabilistic β-oscillations.https://www.mdpi.com/2306-5354/10/8/898local field potentialslead-DBSsubthalamic nucleusParkinson’s disease |
| spellingShingle | Colette Boëx Abdullah Al Awadhi Rémi Tyrand Marco V. Corniola Astrid Kibleur Vanessa Fleury Pierre R. Burkhard Shahan Momjian Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes Bioengineering local field potentials lead-DBS subthalamic nucleus Parkinson’s disease |
| title | Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes |
| title_full | Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes |
| title_fullStr | Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes |
| title_full_unstemmed | Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes |
| title_short | Validation of Lead-DBS β-Oscillation Localization with Directional Electrodes |
| title_sort | validation of lead dbs β oscillation localization with directional electrodes |
| topic | local field potentials lead-DBS subthalamic nucleus Parkinson’s disease |
| url | https://www.mdpi.com/2306-5354/10/8/898 |
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