Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair
Neurological disorders affecting both CNS and PNS still represent one of the most critical and challenging pathologies, therefore many researchers have been focusing on this field in recent decades. Spinal cord injury (SCI) and peripheral nerve injury (PNI) are severely disabling diseases leading to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/2/400 |
| _version_ | 1797618737497505792 |
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| author | Caterina Valentino Barbara Vigani Giuseppina Sandri Franca Ferrari Silvia Rossi |
| author_facet | Caterina Valentino Barbara Vigani Giuseppina Sandri Franca Ferrari Silvia Rossi |
| author_sort | Caterina Valentino |
| collection | DOAJ |
| description | Neurological disorders affecting both CNS and PNS still represent one of the most critical and challenging pathologies, therefore many researchers have been focusing on this field in recent decades. Spinal cord injury (SCI) and peripheral nerve injury (PNI) are severely disabling diseases leading to dramatic and, in most cases, irreversible sensory, motor, and autonomic impairments. The challenging pathophysiologic consequences involved in SCI and PNI are demanding the development of more effective therapeutic strategies since, as yet, a therapeutic strategy that can effectively lead to a complete recovery from such pathologies is not available. Drug delivery systems (DDSs) based on polysaccharides have been receiving more and more attention for a wide range of applications, due to their outstanding physical-chemical properties. This review aims at providing an overview of the most studied polysaccharides used for the development of DDSs intended for the repair and regeneration of a damaged nervous system, with particular attention to spinal cord and peripheral nerve injury treatments. In particular, DDSs based on chitosan and their association with alginate, dextran, agarose, cellulose, and gellan were thoroughly revised. |
| first_indexed | 2024-03-11T08:16:43Z |
| format | Article |
| id | doaj.art-42b538ed72514e748229f64e709f75f8 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T08:16:43Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-42b538ed72514e748229f64e709f75f82023-11-16T22:39:26ZengMDPI AGPharmaceutics1999-49232023-01-0115240010.3390/pharmaceutics15020400Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries RepairCaterina Valentino0Barbara Vigani1Giuseppina Sandri2Franca Ferrari3Silvia Rossi4Department of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, ItalyNeurological disorders affecting both CNS and PNS still represent one of the most critical and challenging pathologies, therefore many researchers have been focusing on this field in recent decades. Spinal cord injury (SCI) and peripheral nerve injury (PNI) are severely disabling diseases leading to dramatic and, in most cases, irreversible sensory, motor, and autonomic impairments. The challenging pathophysiologic consequences involved in SCI and PNI are demanding the development of more effective therapeutic strategies since, as yet, a therapeutic strategy that can effectively lead to a complete recovery from such pathologies is not available. Drug delivery systems (DDSs) based on polysaccharides have been receiving more and more attention for a wide range of applications, due to their outstanding physical-chemical properties. This review aims at providing an overview of the most studied polysaccharides used for the development of DDSs intended for the repair and regeneration of a damaged nervous system, with particular attention to spinal cord and peripheral nerve injury treatments. In particular, DDSs based on chitosan and their association with alginate, dextran, agarose, cellulose, and gellan were thoroughly revised.https://www.mdpi.com/1999-4923/15/2/400polysaccharidesdrug delivery systemsspinal cord injuryperipheral nerve injury |
| spellingShingle | Caterina Valentino Barbara Vigani Giuseppina Sandri Franca Ferrari Silvia Rossi Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair Pharmaceutics polysaccharides drug delivery systems spinal cord injury peripheral nerve injury |
| title | Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair |
| title_full | Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair |
| title_fullStr | Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair |
| title_full_unstemmed | Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair |
| title_short | Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair |
| title_sort | current status of polysaccharides based drug delivery systems for nervous tissue injuries repair |
| topic | polysaccharides drug delivery systems spinal cord injury peripheral nerve injury |
| url | https://www.mdpi.com/1999-4923/15/2/400 |
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