An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation
A 68-year-old woman was admitted to our hospital with a dry cough in 2010. Chest computed tomography showed the appearance of a nonspecific interstitial pneumonia (NSIP) pattern. Video-assisted thoracoscopic surgery (VATS) was performed, and the specimens prominently showed a usual interstitial pneu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007117304008 |
| _version_ | 1831724378143850496 |
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| author | Hironori Mikumo Toyoshi Yanagihara Naoki Hamada Mikiko Hashisako Kayo Ijichi Kunihiro Suzuki Eiji Harada Yasunori Shikada Yoshinao Oda Yoichi Nakanishi |
| author_facet | Hironori Mikumo Toyoshi Yanagihara Naoki Hamada Mikiko Hashisako Kayo Ijichi Kunihiro Suzuki Eiji Harada Yasunori Shikada Yoshinao Oda Yoichi Nakanishi |
| author_sort | Hironori Mikumo |
| collection | DOAJ |
| description | A 68-year-old woman was admitted to our hospital with a dry cough in 2010. Chest computed tomography showed the appearance of a nonspecific interstitial pneumonia (NSIP) pattern. Video-assisted thoracoscopic surgery (VATS) was performed, and the specimens prominently showed a usual interstitial pneumonia (UIP) pattern. She was diagnosed with bird-related chronic hypersensitivity pneumonitis (BRCHP) on the basis of the detection of antibodies to pigeon dropping extract in her serum and a history of using feather-filled duvets and indirect exposure to birds in her living environment. Even though she was treated with corticosteroids and immunosuppressants and recommended to avoid bird-related antigens, she had a progressive course with repeated acute exacerbation episodes and died of respiratory failure. The autopsy findings showed diffuse alveolar damage superimposed on UIP. Clinicians should be aware that BRCHP patients especially with histopathologically UIP pattern may experience acute exacerbation. Keywords: Acute exacerbation, Autopsy, Bird-related chronic hypersensitivity pneumonitis, Interstitial pneumonia, Pigeon dropping extracts |
| first_indexed | 2024-12-21T04:20:55Z |
| format | Article |
| id | doaj.art-42b61080d9744513bfae7830411f319a |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-21T04:20:55Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-42b61080d9744513bfae7830411f319a2022-12-21T19:16:10ZengElsevierRespiratory Medicine Case Reports2213-00712018-01-01249294An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbationHironori Mikumo0Toyoshi Yanagihara1Naoki Hamada2Mikiko Hashisako3Kayo Ijichi4Kunihiro Suzuki5Eiji Harada6Yasunori Shikada7Yoshinao Oda8Yoichi Nakanishi9Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan; Corresponding author. Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan; Department of Pathology, Nagasaki University Hospital, Nagasaki University, JapanDepartment of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, JapanDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, JapanDepartment of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, JapanA 68-year-old woman was admitted to our hospital with a dry cough in 2010. Chest computed tomography showed the appearance of a nonspecific interstitial pneumonia (NSIP) pattern. Video-assisted thoracoscopic surgery (VATS) was performed, and the specimens prominently showed a usual interstitial pneumonia (UIP) pattern. She was diagnosed with bird-related chronic hypersensitivity pneumonitis (BRCHP) on the basis of the detection of antibodies to pigeon dropping extract in her serum and a history of using feather-filled duvets and indirect exposure to birds in her living environment. Even though she was treated with corticosteroids and immunosuppressants and recommended to avoid bird-related antigens, she had a progressive course with repeated acute exacerbation episodes and died of respiratory failure. The autopsy findings showed diffuse alveolar damage superimposed on UIP. Clinicians should be aware that BRCHP patients especially with histopathologically UIP pattern may experience acute exacerbation. Keywords: Acute exacerbation, Autopsy, Bird-related chronic hypersensitivity pneumonitis, Interstitial pneumonia, Pigeon dropping extractshttp://www.sciencedirect.com/science/article/pii/S2213007117304008 |
| spellingShingle | Hironori Mikumo Toyoshi Yanagihara Naoki Hamada Mikiko Hashisako Kayo Ijichi Kunihiro Suzuki Eiji Harada Yasunori Shikada Yoshinao Oda Yoichi Nakanishi An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation Respiratory Medicine Case Reports |
| title | An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation |
| title_full | An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation |
| title_fullStr | An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation |
| title_full_unstemmed | An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation |
| title_short | An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation |
| title_sort | autopsy case of bird related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation |
| url | http://www.sciencedirect.com/science/article/pii/S2213007117304008 |
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