Rheological properties of blood in multiple myeloma patients
Abstract Multiple myeloma (MM) is considered to be one of the hematological malignancies formed by excessive and abnormal proliferation of plasmocytes. Among other parameters, several blood tests are used to diagnose multiple myeloma. The hemorheological profile in multiple myeloma is not widely stu...
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-54947-4 |
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| author | Bartłomiej Ptaszek Szymon Podsiadło Zuzanna Jandziś Aneta Teległów Anna Piotrowska Artur Jurczyszyn Olga Czerwińska-Ledwig |
| author_facet | Bartłomiej Ptaszek Szymon Podsiadło Zuzanna Jandziś Aneta Teległów Anna Piotrowska Artur Jurczyszyn Olga Czerwińska-Ledwig |
| author_sort | Bartłomiej Ptaszek |
| collection | DOAJ |
| description | Abstract Multiple myeloma (MM) is considered to be one of the hematological malignancies formed by excessive and abnormal proliferation of plasmocytes. Among other parameters, several blood tests are used to diagnose multiple myeloma. The hemorheological profile in multiple myeloma is not widely studied. Hemorheology includes the study of measuring the deformability and aggregation of erythrocytes, blood viscosity, and sedimentation rate. The degree of deformability of blood cells is necessary to maintain proper vital functions. Proper deformability of red blood cells ensures proper blood circulation, tissue oxidation and carbon dioxide uptake. The aim of the study was to compare morphology and blood rheology parameters in patients with MM and healthy individuals. The study included 33 patients with MM, and 33 healthy subjects of the same age. The hematological blood parameters were evaluated using ABX MICROS 60 hematology analyzer. The LORCA Analyzer to study erythrocyte aggregation and deformability. Patients with MM had lower red blood cells count (RBC) (9.11%) (p < 0.001) and half time of total aggregation (T1/2) (94.29%) (p < 0.001) values and higher mean corpuscular volume (MCV) (5.50%) (p < 0.001), aggregation index (AI) (68.60%) (p < 0.001), total extent of aggregation (AMP) (87.92%) (p < 0.001) values than the healthy control group. Aggregation in patients with MM is different compared to healthy individuals. It was observed that the percentage of cell aggregation is almost 50% higher than in the control group. The study of morphology, aggregation and deformability of erythrocytes in patients with suspected MM may be helpful in making clinical decisions. |
| first_indexed | 2024-03-07T15:10:56Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:10:56Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-42b8e2ed63424c0fb8c97ee6f50695122024-03-05T18:39:40ZengNature PortfolioScientific Reports2045-23222024-02-011411610.1038/s41598-024-54947-4Rheological properties of blood in multiple myeloma patientsBartłomiej Ptaszek0Szymon Podsiadło1Zuzanna Jandziś2Aneta Teległów3Anna Piotrowska4Artur Jurczyszyn5Olga Czerwińska-Ledwig6Institute of Applied Sciences, University of Physical Education in KrakowInstitute of Clinical Rehabilitation, University of Physical Education in KrakowFaculty of Motor Rehabilitation, University of Physical Education in KrakowInstitute of Basic Sciences, University of Physical Education in KrakowInstitute of Basic Sciences, University of Physical Education in KrakowDepartment of Hematology, Jagiellonian University Medical CollegeInstitute of Basic Sciences, University of Physical Education in KrakowAbstract Multiple myeloma (MM) is considered to be one of the hematological malignancies formed by excessive and abnormal proliferation of plasmocytes. Among other parameters, several blood tests are used to diagnose multiple myeloma. The hemorheological profile in multiple myeloma is not widely studied. Hemorheology includes the study of measuring the deformability and aggregation of erythrocytes, blood viscosity, and sedimentation rate. The degree of deformability of blood cells is necessary to maintain proper vital functions. Proper deformability of red blood cells ensures proper blood circulation, tissue oxidation and carbon dioxide uptake. The aim of the study was to compare morphology and blood rheology parameters in patients with MM and healthy individuals. The study included 33 patients with MM, and 33 healthy subjects of the same age. The hematological blood parameters were evaluated using ABX MICROS 60 hematology analyzer. The LORCA Analyzer to study erythrocyte aggregation and deformability. Patients with MM had lower red blood cells count (RBC) (9.11%) (p < 0.001) and half time of total aggregation (T1/2) (94.29%) (p < 0.001) values and higher mean corpuscular volume (MCV) (5.50%) (p < 0.001), aggregation index (AI) (68.60%) (p < 0.001), total extent of aggregation (AMP) (87.92%) (p < 0.001) values than the healthy control group. Aggregation in patients with MM is different compared to healthy individuals. It was observed that the percentage of cell aggregation is almost 50% higher than in the control group. The study of morphology, aggregation and deformability of erythrocytes in patients with suspected MM may be helpful in making clinical decisions.https://doi.org/10.1038/s41598-024-54947-4Blood rheologyRed blood cellRed blood cell deformabilityRed blood cell aggregationMultiple myeloma |
| spellingShingle | Bartłomiej Ptaszek Szymon Podsiadło Zuzanna Jandziś Aneta Teległów Anna Piotrowska Artur Jurczyszyn Olga Czerwińska-Ledwig Rheological properties of blood in multiple myeloma patients Scientific Reports Blood rheology Red blood cell Red blood cell deformability Red blood cell aggregation Multiple myeloma |
| title | Rheological properties of blood in multiple myeloma patients |
| title_full | Rheological properties of blood in multiple myeloma patients |
| title_fullStr | Rheological properties of blood in multiple myeloma patients |
| title_full_unstemmed | Rheological properties of blood in multiple myeloma patients |
| title_short | Rheological properties of blood in multiple myeloma patients |
| title_sort | rheological properties of blood in multiple myeloma patients |
| topic | Blood rheology Red blood cell Red blood cell deformability Red blood cell aggregation Multiple myeloma |
| url | https://doi.org/10.1038/s41598-024-54947-4 |
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