High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer
<p><b>Objective</b>: To investigate the incidence of high-risk human papillomavirus (HPV) infection and its clinical meaning.</p><p><b>Methods</b>: Total 28,339 women attending our hospital for routine gynecologic care underwent Papanicolaou test (PAP test)...
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Format: | Article |
Language: | English |
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Ivyspring International Publisher
2012-01-01
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Series: | International Journal of Medical Sciences |
Online Access: | http://www.medsci.org/v09p0103.htm |
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author | Sung Jong Lee, Seung Geun Yeo, Dong Choon Park |
author_facet | Sung Jong Lee, Seung Geun Yeo, Dong Choon Park |
author_sort | Sung Jong Lee, Seung Geun Yeo, Dong Choon Park |
collection | DOAJ |
description | <p><b>Objective</b>: To investigate the incidence of high-risk human papillomavirus (HPV) infection and its clinical meaning.</p><p><b>Methods</b>: Total 28,339 women attending our hospital for routine gynecologic care underwent Papanicolaou test (PAP test) and high-risk HPV tests. Biopsies were taken from some women and their results were compared.</p><p><b>Results</b>: The prevalence of high-risk HPV infection is 24.15%. And the women aged 20-29 years had the highest prevalence (32.3%) compared to 30-70 years (P<0.05). Of the 28,339 women, 1369 (4.83%) had positive PAP test (ASCUS, LSIL, HSIL). Of the 1369 PAP-positive patients, only 16 (1.17%) were negative for HPV test. Of the 1353 patients positive on both tests, 510 (37.7%) had lesions higher than CINII on histology. Of the 1,611 patients who underwent biopsies, 350 underwent the loop electrical excision procedure, with 339 (96%) being positive for HPV test, including 16 with CINI, 48 with CINII/III, 74 with CIS, and 16 with cervical cancer. HPV test had a positive predictive value of 40.7% and a negative predictive value of 100% for higher than CINII.</p><p><b>Conclusion:</b> Although HPV test has a burden of cost, considering its high negative predictive value, HPV test should be considered for more useful screening test.</p> |
first_indexed | 2024-04-13T06:55:56Z |
format | Article |
id | doaj.art-42ba381feccf4941a7835ff2877efa06 |
institution | Directory Open Access Journal |
issn | 1449-1907 |
language | English |
last_indexed | 2024-04-13T06:55:56Z |
publishDate | 2012-01-01 |
publisher | Ivyspring International Publisher |
record_format | Article |
series | International Journal of Medical Sciences |
spelling | doaj.art-42ba381feccf4941a7835ff2877efa062022-12-22T02:57:15ZengIvyspring International PublisherInternational Journal of Medical Sciences1449-19072012-01-0191103107High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical CancerSung Jong Lee, Seung Geun Yeo, Dong Choon Park<p><b>Objective</b>: To investigate the incidence of high-risk human papillomavirus (HPV) infection and its clinical meaning.</p><p><b>Methods</b>: Total 28,339 women attending our hospital for routine gynecologic care underwent Papanicolaou test (PAP test) and high-risk HPV tests. Biopsies were taken from some women and their results were compared.</p><p><b>Results</b>: The prevalence of high-risk HPV infection is 24.15%. And the women aged 20-29 years had the highest prevalence (32.3%) compared to 30-70 years (P<0.05). Of the 28,339 women, 1369 (4.83%) had positive PAP test (ASCUS, LSIL, HSIL). Of the 1369 PAP-positive patients, only 16 (1.17%) were negative for HPV test. Of the 1353 patients positive on both tests, 510 (37.7%) had lesions higher than CINII on histology. Of the 1,611 patients who underwent biopsies, 350 underwent the loop electrical excision procedure, with 339 (96%) being positive for HPV test, including 16 with CINI, 48 with CINII/III, 74 with CIS, and 16 with cervical cancer. HPV test had a positive predictive value of 40.7% and a negative predictive value of 100% for higher than CINII.</p><p><b>Conclusion:</b> Although HPV test has a burden of cost, considering its high negative predictive value, HPV test should be considered for more useful screening test.</p>http://www.medsci.org/v09p0103.htm |
spellingShingle | Sung Jong Lee, Seung Geun Yeo, Dong Choon Park High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer International Journal of Medical Sciences |
title | High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer |
title_full | High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer |
title_fullStr | High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer |
title_full_unstemmed | High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer |
title_short | High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer |
title_sort | high risk human papillomavirus infection in low risk women incidence patient characteristics and clinical meaning for cervical cancer |
url | http://www.medsci.org/v09p0103.htm |
work_keys_str_mv | AT sungjongleeseunggeunyeodongchoonpark highriskhumanpapillomavirusinfectioninlowriskwomenincidencepatientcharacteristicsandclinicalmeaningforcervicalcancer |