Cuproptosis in stroke: focusing on pathogenesis and treatment
Annually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability rates. This disease significantly affects daily life, impairing everyday functioning, executive function, and cognition. Moreover, stroke severely restricts patients’ ability to pe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1349123/full |
| _version_ | 1797238455540908032 |
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| author | Liwei Xing Zhifeng Wang Zhihui Hao Pan Pan Aiming Yang Jian Wang |
| author_facet | Liwei Xing Zhifeng Wang Zhihui Hao Pan Pan Aiming Yang Jian Wang |
| author_sort | Liwei Xing |
| collection | DOAJ |
| description | Annually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability rates. This disease significantly affects daily life, impairing everyday functioning, executive function, and cognition. Moreover, stroke severely restricts patients’ ability to perform daily activities, diminishing their overall quality of life. Recent scientific studies have identified cuproptosis, a newly discovered form of cell death, as a key factor in stroke development. However, the role of cuproptosis in stroke remains unclear to researchers. Therefore, it is crucial to investigate the mechanisms of cuproptosis in stroke’s pathogenesis. This review examines the physiological role of copper, the characteristics and mechanisms of cuproptosis, the differences and similarities between cuproptosis and other cell death types, and the pathophysiology of cuproptosis in stroke, focusing on mitochondrial dysfunction and immune infiltration. Further research is necessary to understand the relationship between previous strokes and cuproptosis and to clarify the mechanisms behind these associations. |
| first_indexed | 2024-04-24T17:35:55Z |
| format | Article |
| id | doaj.art-42ba5a654a2948ffb26abe16547a4698 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-24T17:35:55Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-42ba5a654a2948ffb26abe16547a46982024-03-28T05:06:22ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992024-03-011710.3389/fnmol.2024.13491231349123Cuproptosis in stroke: focusing on pathogenesis and treatmentLiwei Xing0Zhifeng Wang1Zhihui Hao2Pan Pan3Aiming Yang4Jian Wang5The First Clinical Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, ChinaThe First Clinical Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, ChinaThe First Clinical Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, ChinaCollege of Acupuncture and Massage, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, ChinaYunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan, ChinaThe First Clinical Medical School, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, ChinaAnnually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability rates. This disease significantly affects daily life, impairing everyday functioning, executive function, and cognition. Moreover, stroke severely restricts patients’ ability to perform daily activities, diminishing their overall quality of life. Recent scientific studies have identified cuproptosis, a newly discovered form of cell death, as a key factor in stroke development. However, the role of cuproptosis in stroke remains unclear to researchers. Therefore, it is crucial to investigate the mechanisms of cuproptosis in stroke’s pathogenesis. This review examines the physiological role of copper, the characteristics and mechanisms of cuproptosis, the differences and similarities between cuproptosis and other cell death types, and the pathophysiology of cuproptosis in stroke, focusing on mitochondrial dysfunction and immune infiltration. Further research is necessary to understand the relationship between previous strokes and cuproptosis and to clarify the mechanisms behind these associations.https://www.frontiersin.org/articles/10.3389/fnmol.2024.1349123/fullstrokecuproptosispathogenesistreatmentmechanism |
| spellingShingle | Liwei Xing Zhifeng Wang Zhihui Hao Pan Pan Aiming Yang Jian Wang Cuproptosis in stroke: focusing on pathogenesis and treatment Frontiers in Molecular Neuroscience stroke cuproptosis pathogenesis treatment mechanism |
| title | Cuproptosis in stroke: focusing on pathogenesis and treatment |
| title_full | Cuproptosis in stroke: focusing on pathogenesis and treatment |
| title_fullStr | Cuproptosis in stroke: focusing on pathogenesis and treatment |
| title_full_unstemmed | Cuproptosis in stroke: focusing on pathogenesis and treatment |
| title_short | Cuproptosis in stroke: focusing on pathogenesis and treatment |
| title_sort | cuproptosis in stroke focusing on pathogenesis and treatment |
| topic | stroke cuproptosis pathogenesis treatment mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1349123/full |
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