Enzyme-Like Properties of Gold Clusters for Biomedical Application
In recent years, the rapid development of nanoscience and technology has provided a new opportunity for the development and preparation of new inorganic enzymes. Nanozyme is a new generation of artificial mimetic enzyme, which like natural enzymes, can efficiently catalyze the substrate of enzyme un...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2020.00219/full |
| _version_ | 1819129193023143936 |
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| author | Yunguang Zhang Shuo Li Haile Liu Wei Long Xiao-Dong Zhang |
| author_facet | Yunguang Zhang Shuo Li Haile Liu Wei Long Xiao-Dong Zhang |
| author_sort | Yunguang Zhang |
| collection | DOAJ |
| description | In recent years, the rapid development of nanoscience and technology has provided a new opportunity for the development and preparation of new inorganic enzymes. Nanozyme is a new generation of artificial mimetic enzyme, which like natural enzymes, can efficiently catalyze the substrate of enzyme under mild conditions, exhibiting catalytic efficiency, and enzymatic reaction kinetics similar to natural enzymes. However, nanozymes exist better stability than native enzymes, it can still maintain 85 % catalytic activity in strong acid and alkali (pH 2~10) or large temperature range (4~90°C). This provides conditions for designing complex catalytic systems. In this review, we discussed the enzymatic attributes and biomedical applications of gold nanoclusters, including peroxidase-like, catalase-like, detection of heavy metal ions, and therapy of brain and cancer etc. This review can help us understand the current research status nanozymes. |
| first_indexed | 2024-12-22T08:39:49Z |
| format | Article |
| id | doaj.art-42bcb4f9db8e41058fee8af67cd66d07 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-22T08:39:49Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-42bcb4f9db8e41058fee8af67cd66d072022-12-21T18:32:15ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-04-01810.3389/fchem.2020.00219524264Enzyme-Like Properties of Gold Clusters for Biomedical ApplicationYunguang Zhang0Shuo Li1Haile Liu2Wei Long3Xiao-Dong Zhang4School of Science, Xi'an University of Posts and Telecommunications, Xi'an, ChinaSchool of Science, Xi'an University of Posts and Telecommunications, Xi'an, ChinaDepartment of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, ChinaInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaDepartment of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, ChinaIn recent years, the rapid development of nanoscience and technology has provided a new opportunity for the development and preparation of new inorganic enzymes. Nanozyme is a new generation of artificial mimetic enzyme, which like natural enzymes, can efficiently catalyze the substrate of enzyme under mild conditions, exhibiting catalytic efficiency, and enzymatic reaction kinetics similar to natural enzymes. However, nanozymes exist better stability than native enzymes, it can still maintain 85 % catalytic activity in strong acid and alkali (pH 2~10) or large temperature range (4~90°C). This provides conditions for designing complex catalytic systems. In this review, we discussed the enzymatic attributes and biomedical applications of gold nanoclusters, including peroxidase-like, catalase-like, detection of heavy metal ions, and therapy of brain and cancer etc. This review can help us understand the current research status nanozymes.https://www.frontiersin.org/article/10.3389/fchem.2020.00219/fullgold nanoclustersnanozymeenzyme-like propertiescancer therapybio-detection |
| spellingShingle | Yunguang Zhang Shuo Li Haile Liu Wei Long Xiao-Dong Zhang Enzyme-Like Properties of Gold Clusters for Biomedical Application Frontiers in Chemistry gold nanoclusters nanozyme enzyme-like properties cancer therapy bio-detection |
| title | Enzyme-Like Properties of Gold Clusters for Biomedical Application |
| title_full | Enzyme-Like Properties of Gold Clusters for Biomedical Application |
| title_fullStr | Enzyme-Like Properties of Gold Clusters for Biomedical Application |
| title_full_unstemmed | Enzyme-Like Properties of Gold Clusters for Biomedical Application |
| title_short | Enzyme-Like Properties of Gold Clusters for Biomedical Application |
| title_sort | enzyme like properties of gold clusters for biomedical application |
| topic | gold nanoclusters nanozyme enzyme-like properties cancer therapy bio-detection |
| url | https://www.frontiersin.org/article/10.3389/fchem.2020.00219/full |
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