Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational study
<p>Abstract</p> <p>Background</p> <p>Patients on peritoneal and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. The atherosclerosis is associated with increased arterial stiffness, endothelial dysfunct...
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| Format: | Article |
| Language: | English |
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BMC
2009-03-01
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| Series: | BMC Nephrology |
| Online Access: | http://www.biomedcentral.com/1471-2369/10/8 |
| _version_ | 1811284164120412160 |
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| author | Ratanjee Sharad Ranganathan Dwarakanathan Healy Helen Driver Ritza Fassett Robert G Robertson Iain K Geraghty Dominic P Sharman James E Coombes Jeff S |
| author_facet | Ratanjee Sharad Ranganathan Dwarakanathan Healy Helen Driver Ritza Fassett Robert G Robertson Iain K Geraghty Dominic P Sharman James E Coombes Jeff S |
| author_sort | Ratanjee Sharad |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Patients on peritoneal and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. The atherosclerosis is associated with increased arterial stiffness, endothelial dysfunction and elevated oxidative stress and inflammation. The aims of this study are to investigate the effects of peritoneal and hemodialysis on arterial stiffness, vascular function, myocardial structure and function, oxidative stress and inflammation in incident patients with end stage kidney disease.</p> <p>Methods</p> <p>This is an observational study. Eighty stage five CKD patients will be enrolled and followed for one-year. Primary outcome measures will be changes in 1) arterial stiffness measured by aortic pulse wave velocity, 2) oxidative stress assessed by plasma F<sub>2 </sub>isoprostanes and 3) inflammation measured by plasma pentraxin-3. Secondary outcomes will include additional measures of oxidative stress and inflammation, changes in vascular function assessed using the brachial artery reactivity technique, carotid artery intimal medial thickness, augmentation index and trans thoracic echocardiography to assess left ventricular geometry, and systolic and diastolic function. Patients will undergo these measures at baseline (6–8 weeks prior to starting dialysis therapy), then at six and 12 months after starting dialysis.</p> <p>Discussion</p> <p>The results of this study may guide the choice of dialysis modality in the first year of treatment. It may also lead to a larger study prospectively assessing the effect of dialysis modality on cardiovascular morbidity and mortality.</p> <p>Trial Registration</p> <p>ACTRN12609000049279</p> |
| first_indexed | 2024-04-13T02:24:36Z |
| format | Article |
| id | doaj.art-42bd5c920cb84311ac593510900f0246 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-13T02:24:36Z |
| publishDate | 2009-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-42bd5c920cb84311ac593510900f02462022-12-22T03:06:49ZengBMCBMC Nephrology1471-23692009-03-01101810.1186/1471-2369-10-8Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational studyRatanjee SharadRanganathan DwarakanathanHealy HelenDriver RitzaFassett Robert GRobertson Iain KGeraghty Dominic PSharman James ECoombes Jeff S<p>Abstract</p> <p>Background</p> <p>Patients on peritoneal and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. The atherosclerosis is associated with increased arterial stiffness, endothelial dysfunction and elevated oxidative stress and inflammation. The aims of this study are to investigate the effects of peritoneal and hemodialysis on arterial stiffness, vascular function, myocardial structure and function, oxidative stress and inflammation in incident patients with end stage kidney disease.</p> <p>Methods</p> <p>This is an observational study. Eighty stage five CKD patients will be enrolled and followed for one-year. Primary outcome measures will be changes in 1) arterial stiffness measured by aortic pulse wave velocity, 2) oxidative stress assessed by plasma F<sub>2 </sub>isoprostanes and 3) inflammation measured by plasma pentraxin-3. Secondary outcomes will include additional measures of oxidative stress and inflammation, changes in vascular function assessed using the brachial artery reactivity technique, carotid artery intimal medial thickness, augmentation index and trans thoracic echocardiography to assess left ventricular geometry, and systolic and diastolic function. Patients will undergo these measures at baseline (6–8 weeks prior to starting dialysis therapy), then at six and 12 months after starting dialysis.</p> <p>Discussion</p> <p>The results of this study may guide the choice of dialysis modality in the first year of treatment. It may also lead to a larger study prospectively assessing the effect of dialysis modality on cardiovascular morbidity and mortality.</p> <p>Trial Registration</p> <p>ACTRN12609000049279</p>http://www.biomedcentral.com/1471-2369/10/8 |
| spellingShingle | Ratanjee Sharad Ranganathan Dwarakanathan Healy Helen Driver Ritza Fassett Robert G Robertson Iain K Geraghty Dominic P Sharman James E Coombes Jeff S Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational study BMC Nephrology |
| title | Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational study |
| title_full | Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational study |
| title_fullStr | Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational study |
| title_full_unstemmed | Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational study |
| title_short | Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients – an observational study |
| title_sort | comparison of markers of oxidative stress inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients an observational study |
| url | http://www.biomedcentral.com/1471-2369/10/8 |
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