The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers
Abstract Background and aims Current research has suggested that asialoglycoprotein receptor 1 (ASGR1) is involved in cholesterol metabolism and is also related to systemic inflammation. This study aimed to assess the correlation between the serum soluble ASGR1 (sASGR1) concentration and inflammator...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-024-02054-8 |
| _version_ | 1797233244454780928 |
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| author | Qin Luo Jingfei Chen Yanfeng Yi Panyun Wu Yingjie Su Zhangling Chen Hacı Ahmet Aydemir Jianjun Tang Zhenfei Fang Fei Luo |
| author_facet | Qin Luo Jingfei Chen Yanfeng Yi Panyun Wu Yingjie Su Zhangling Chen Hacı Ahmet Aydemir Jianjun Tang Zhenfei Fang Fei Luo |
| author_sort | Qin Luo |
| collection | DOAJ |
| description | Abstract Background and aims Current research has suggested that asialoglycoprotein receptor 1 (ASGR1) is involved in cholesterol metabolism and is also related to systemic inflammation. This study aimed to assess the correlation between the serum soluble ASGR1 (sASGR1) concentration and inflammatory marker levels. Moreover, the second objective of the study was to assess the association between sASGR1 levels and the presence of coronary artery disease (CAD). Methods The study subjects included 160 patients who underwent coronary angiography. Ninety patients were diagnosed with CAD, while seventy age- and sex-matched non-CAD patients served as controls. We measured the serum sASGR1 levels using an ELISA kit after collecting clinical baseline characteristics. Results Patients with CAD had higher serum sASGR1 levels than non-CAD patients did (P < 0.0001). sASGR1 was independently correlated with the risk of CAD after adjusting for confounding variables (OR = 1.522, P = 0.012). The receiver operating characteristic (ROC) curve showed that sASGR1 had a larger area under the curve (AUC) than did the conventional biomarkers apolipoprotein B (APO-B) and low-density lipoprotein cholesterol (LDL-C). In addition, multivariate linear regression models revealed that sASGR1 is independently and positively correlated with high-sensitivity C-reactive protein (CRP) (β = 0.86, P < 0.001) and WBC (β = 0.13, P = 0.004) counts even after adjusting for lipid parameters. According to our subgroup analysis, this relationship existed only for CAD patients. Conclusion Our research demonstrated the link between CAD and sASGR1 levels, suggesting that sASGR1 may be an independent risk factor for CAD. In addition, this study provides a reference for revealing the potential role of sASGR1 in the inflammation of atherosclerosis. |
| first_indexed | 2024-04-24T16:13:05Z |
| format | Article |
| id | doaj.art-42bdc5fd3cbb47ccbcf0d8599a5563ed |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-24T16:13:05Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-42bdc5fd3cbb47ccbcf0d8599a5563ed2024-03-31T11:33:49ZengBMCLipids in Health and Disease1476-511X2024-03-0123111010.1186/s12944-024-02054-8The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markersQin Luo0Jingfei Chen1Yanfeng Yi2Panyun Wu3Yingjie Su4Zhangling Chen5Hacı Ahmet Aydemir6Jianjun Tang7Zhenfei Fang8Fei Luo9Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South UniversityReproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, Hengyang Medical School, The Affiliated Changsha Central Hospital, University of South ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South UniversityKayakyolu Family Health CenterDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South UniversityAbstract Background and aims Current research has suggested that asialoglycoprotein receptor 1 (ASGR1) is involved in cholesterol metabolism and is also related to systemic inflammation. This study aimed to assess the correlation between the serum soluble ASGR1 (sASGR1) concentration and inflammatory marker levels. Moreover, the second objective of the study was to assess the association between sASGR1 levels and the presence of coronary artery disease (CAD). Methods The study subjects included 160 patients who underwent coronary angiography. Ninety patients were diagnosed with CAD, while seventy age- and sex-matched non-CAD patients served as controls. We measured the serum sASGR1 levels using an ELISA kit after collecting clinical baseline characteristics. Results Patients with CAD had higher serum sASGR1 levels than non-CAD patients did (P < 0.0001). sASGR1 was independently correlated with the risk of CAD after adjusting for confounding variables (OR = 1.522, P = 0.012). The receiver operating characteristic (ROC) curve showed that sASGR1 had a larger area under the curve (AUC) than did the conventional biomarkers apolipoprotein B (APO-B) and low-density lipoprotein cholesterol (LDL-C). In addition, multivariate linear regression models revealed that sASGR1 is independently and positively correlated with high-sensitivity C-reactive protein (CRP) (β = 0.86, P < 0.001) and WBC (β = 0.13, P = 0.004) counts even after adjusting for lipid parameters. According to our subgroup analysis, this relationship existed only for CAD patients. Conclusion Our research demonstrated the link between CAD and sASGR1 levels, suggesting that sASGR1 may be an independent risk factor for CAD. In addition, this study provides a reference for revealing the potential role of sASGR1 in the inflammation of atherosclerosis.https://doi.org/10.1186/s12944-024-02054-8Soluble asialoglycoprotein receptor 1Lipid metabolismCoronary artery diseaseHigh-sensitivity C-reactive proteinWhite blood cell countInflammation |
| spellingShingle | Qin Luo Jingfei Chen Yanfeng Yi Panyun Wu Yingjie Su Zhangling Chen Hacı Ahmet Aydemir Jianjun Tang Zhenfei Fang Fei Luo The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers Lipids in Health and Disease Soluble asialoglycoprotein receptor 1 Lipid metabolism Coronary artery disease High-sensitivity C-reactive protein White blood cell count Inflammation |
| title | The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers |
| title_full | The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers |
| title_fullStr | The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers |
| title_full_unstemmed | The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers |
| title_short | The serum soluble ASGR1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers |
| title_sort | serum soluble asgr1 concentration is elevated in patients with coronary artery disease and is associated with inflammatory markers |
| topic | Soluble asialoglycoprotein receptor 1 Lipid metabolism Coronary artery disease High-sensitivity C-reactive protein White blood cell count Inflammation |
| url | https://doi.org/10.1186/s12944-024-02054-8 |
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