The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study
Background: Metabolically healthy obesity seems to be a unique phenotype for the risk of cardiometabolic diseases. However, it is not known whether this phenotype is associated with the risk of proteinuria. Methods: Study subjects were 9,185 non-diabetic Japanese male workers aged 40–55 years who ha...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2018-08-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/28/8/28_JE20170082/_pdf |
| _version_ | 1828823050238296064 |
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| author | Shinichiro Uehara Kyoko Kogawa Sato Hideo Koh Mikiko Shibata Shigeki Kinuhata Akiko Yamada Keiko Oue Hiroshi Kambe Michio Morimoto Tomoshige Hayashi |
| author_facet | Shinichiro Uehara Kyoko Kogawa Sato Hideo Koh Mikiko Shibata Shigeki Kinuhata Akiko Yamada Keiko Oue Hiroshi Kambe Michio Morimoto Tomoshige Hayashi |
| author_sort | Shinichiro Uehara |
| collection | DOAJ |
| description | Background: Metabolically healthy obesity seems to be a unique phenotype for the risk of cardiometabolic diseases. However, it is not known whether this phenotype is associated with the risk of proteinuria. Methods: Study subjects were 9,185 non-diabetic Japanese male workers aged 40–55 years who had no proteinuria, an estimated glomerular filtration rate ≥60 mL/min/1.73 m2, no history of cancer, and no use of antihypertensive or lipid-lowering medications at baseline. Obesity was defined as body mass index ≥25.0 kg/m2. Metabolic health was defined as the presence of no Adult Treatment Panel III components of the metabolic syndrome criteria, excluding waist circumference, and metabolic unhealth was defined as the presence of one or more metabolic syndrome components, excluding waist circumference. “Consecutive proteinuria” was considered positive if proteinuria was detected twice consecutively as 1+ or higher on urine dipstick at annual examinations to exclude chance proteinuria as much as possible. Results: During the 81,660 person-years follow-up period, we confirmed 390 cases of consecutive proteinuria. Compared with metabolically healthy non-obesity, metabolically healthy obesity was not associated with the risk of consecutive proteinuria (multiple-adjusted hazard ratio [HR] 0.86; 95% confidence interval [CI], 0.37–1.99), but metabolically unhealthy non-obesity with ≥2 metabolic syndrome components (HR 1.77; 95% CI, 1.30–2.42), metabolically unhealthy obesity with one component (HR 1.71; 95% CI, 1.12–2.61), and metabolically unhealthy obesity with ≥2 metabolic syndrome components (HR 2.77; 95% CI, 2.01–3.82) were associated with an increased risk of consecutive proteinuria. Conclusions: Metabolically healthy obesity did not increase the risk of consecutive proteinuria in Japanese middle-aged men. |
| first_indexed | 2024-12-12T13:27:17Z |
| format | Article |
| id | doaj.art-42bf4bb2e4e44aac8724e5c1c9920042 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-12T13:27:17Z |
| publishDate | 2018-08-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-42bf4bb2e4e44aac8724e5c1c99200422022-12-22T00:23:09ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922018-08-0128836136610.2188/jea.JE20170082The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare StudyShinichiro Uehara0Kyoko Kogawa Sato1Hideo Koh2Mikiko Shibata3Shigeki Kinuhata4Akiko Yamada5Keiko Oue6Hiroshi Kambe7Michio Morimoto8Tomoshige Hayashi9Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanHematology, Osaka City University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanMedical Education and General Practice, Osaka City University Graduate School of Medicine, Osaka, JapanOsaka City University Hospital, Osaka, JapanKansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, JapanKansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, JapanKansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanBackground: Metabolically healthy obesity seems to be a unique phenotype for the risk of cardiometabolic diseases. However, it is not known whether this phenotype is associated with the risk of proteinuria. Methods: Study subjects were 9,185 non-diabetic Japanese male workers aged 40–55 years who had no proteinuria, an estimated glomerular filtration rate ≥60 mL/min/1.73 m2, no history of cancer, and no use of antihypertensive or lipid-lowering medications at baseline. Obesity was defined as body mass index ≥25.0 kg/m2. Metabolic health was defined as the presence of no Adult Treatment Panel III components of the metabolic syndrome criteria, excluding waist circumference, and metabolic unhealth was defined as the presence of one or more metabolic syndrome components, excluding waist circumference. “Consecutive proteinuria” was considered positive if proteinuria was detected twice consecutively as 1+ or higher on urine dipstick at annual examinations to exclude chance proteinuria as much as possible. Results: During the 81,660 person-years follow-up period, we confirmed 390 cases of consecutive proteinuria. Compared with metabolically healthy non-obesity, metabolically healthy obesity was not associated with the risk of consecutive proteinuria (multiple-adjusted hazard ratio [HR] 0.86; 95% confidence interval [CI], 0.37–1.99), but metabolically unhealthy non-obesity with ≥2 metabolic syndrome components (HR 1.77; 95% CI, 1.30–2.42), metabolically unhealthy obesity with one component (HR 1.71; 95% CI, 1.12–2.61), and metabolically unhealthy obesity with ≥2 metabolic syndrome components (HR 2.77; 95% CI, 2.01–3.82) were associated with an increased risk of consecutive proteinuria. Conclusions: Metabolically healthy obesity did not increase the risk of consecutive proteinuria in Japanese middle-aged men.https://www.jstage.jst.go.jp/article/jea/28/8/28_JE20170082/_pdfmetabolically healthy obese phenotypemetabolically healthy obesityproteinuriachronic kidney diseaseprospective study |
| spellingShingle | Shinichiro Uehara Kyoko Kogawa Sato Hideo Koh Mikiko Shibata Shigeki Kinuhata Akiko Yamada Keiko Oue Hiroshi Kambe Michio Morimoto Tomoshige Hayashi The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study Journal of Epidemiology metabolically healthy obese phenotype metabolically healthy obesity proteinuria chronic kidney disease prospective study |
| title | The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study |
| title_full | The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study |
| title_fullStr | The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study |
| title_full_unstemmed | The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study |
| title_short | The Association Between Metabolically Healthy Obesity and the Risk of Proteinuria: The Kansai Healthcare Study |
| title_sort | association between metabolically healthy obesity and the risk of proteinuria the kansai healthcare study |
| topic | metabolically healthy obese phenotype metabolically healthy obesity proteinuria chronic kidney disease prospective study |
| url | https://www.jstage.jst.go.jp/article/jea/28/8/28_JE20170082/_pdf |
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