Transient Transfection of the Respiratory Epithelium with Gamma Interferon for Host-Directed Therapy in Pulmonary Tuberculosis

Transient Transfection of the Respiratory Epithelium with Gamma Interferon for Host-Directed Therapy in Pulmonary Tuberculosis

Nebulized gamma interferon (IFN-γ) protein has been studied for clinical safety and efficacy against pulmonary tuberculosis (TB). The protein is expensive, requires a cold chain, and is difficult to deploy in limited-resource, high-incidence settings. We generated a preclinical proof of concept (PoC...

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Bibliographic Details
Main Authors: Reena Bharti, Ashish Srivastava, Trisha Roy, Khushboo Verma, D.V. Siva Reddy, Hasham Shafi, Sonia Verma, Sunil K. Raman, Amit K. Singh, Jyotsna Singh, Lipika Ray, Amit Misra
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gamma interferon
dry powder inhalation
pulmonary tuberculosis
preclinical proof of concept
host-directed therapy
gene delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303358

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