Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study
ObjectiveThyroid cancer (TC) prevalence has been rapidly increasing. While the relationship between thyroid hormones and lipids has been widely investigated, studies regarding dyslipidemia in patients with TC have been scarce and controversial. We aimed to investigate dyslipidemia risk after TC diag...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.893461/full |
| _version_ | 1818157102042972160 |
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| author | Youhyun Song Hye Sun Lee Goeun Park Sang-Wook Kang Ji Won Lee |
| author_facet | Youhyun Song Hye Sun Lee Goeun Park Sang-Wook Kang Ji Won Lee |
| author_sort | Youhyun Song |
| collection | DOAJ |
| description | ObjectiveThyroid cancer (TC) prevalence has been rapidly increasing. While the relationship between thyroid hormones and lipids has been widely investigated, studies regarding dyslipidemia in patients with TC have been scarce and controversial. We aimed to investigate dyslipidemia risk after TC diagnosis compared to the general population without TC.MethodA population-based prospective study was conducted using data from the Korean National Health Insurance Service-National Sample Cohort Database 2.0 (NHIS-NSC DB 2.0), with health insurance claim data of 1,108,369 subjects between 2002 and 2015. The final study sample comprised 466,735 adult subjects without TC or dyslipidemia diagnoses before the index year, 2009. Bidirectional analyses were performed using prospective and retrospective concepts. In the prospective analysis, Kaplan-Meier estimates were calculated and log-rank tests and univariable and multivariable Cox regression analyses were performed to determine the relationship between TC and dyslipidemia. The retrospective analysis involved 1:5 nested case-control matching based on dyslipidemia status and conditional logistic regression analysis.ResultsNo significant difference in dyslipidemia incidence was observed between TC patients and the control group, in either the prospective matched (log-rank P = 0.483) or non-matched (log-rank P = 0.424) analyses, or the retrospective analysis (P = 0.3724). In the prospective analysis, 193 patients after TC diagnosis showed similar risk of developing dyslipidemia with the 466,542 controls during the median 7 years of follow-up (unadjusted hazard ratio [HR], 1.102; 95% confidence interval [CI], 0.878-1.383; adjusted HR, 0.932; 95% CI, 0.707-1.230). Multiple propensity score-adjusted models showed similar results, and 114 patients and 570 matched controls showed an HR of 0.818 (95% CI, 0.598-1.120). In the retrospective comparison of dyslipidemia risk in 170 patients and 277,864 controls, the odds ratio was 0.822 (95% CI, 0.534-1.266).ConclusionsDyslipidemia risk was not significantly different between patients with TC and the general population, in both prospective and retrospective analyses. |
| first_indexed | 2024-12-11T15:08:51Z |
| format | Article |
| id | doaj.art-42c0f74807194b658a5cd57b6d372d00 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T15:08:51Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-42c0f74807194b658a5cd57b6d372d002022-12-22T01:00:49ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-06-011310.3389/fendo.2022.893461893461Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort StudyYouhyun Song0Hye Sun Lee1Goeun Park2Sang-Wook Kang3Ji Won Lee4Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South KoreaBiostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South KoreaBiostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South KoreaThyroid-Endocrine Surgery Division, Department of Surgery, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South KoreaObjectiveThyroid cancer (TC) prevalence has been rapidly increasing. While the relationship between thyroid hormones and lipids has been widely investigated, studies regarding dyslipidemia in patients with TC have been scarce and controversial. We aimed to investigate dyslipidemia risk after TC diagnosis compared to the general population without TC.MethodA population-based prospective study was conducted using data from the Korean National Health Insurance Service-National Sample Cohort Database 2.0 (NHIS-NSC DB 2.0), with health insurance claim data of 1,108,369 subjects between 2002 and 2015. The final study sample comprised 466,735 adult subjects without TC or dyslipidemia diagnoses before the index year, 2009. Bidirectional analyses were performed using prospective and retrospective concepts. In the prospective analysis, Kaplan-Meier estimates were calculated and log-rank tests and univariable and multivariable Cox regression analyses were performed to determine the relationship between TC and dyslipidemia. The retrospective analysis involved 1:5 nested case-control matching based on dyslipidemia status and conditional logistic regression analysis.ResultsNo significant difference in dyslipidemia incidence was observed between TC patients and the control group, in either the prospective matched (log-rank P = 0.483) or non-matched (log-rank P = 0.424) analyses, or the retrospective analysis (P = 0.3724). In the prospective analysis, 193 patients after TC diagnosis showed similar risk of developing dyslipidemia with the 466,542 controls during the median 7 years of follow-up (unadjusted hazard ratio [HR], 1.102; 95% confidence interval [CI], 0.878-1.383; adjusted HR, 0.932; 95% CI, 0.707-1.230). Multiple propensity score-adjusted models showed similar results, and 114 patients and 570 matched controls showed an HR of 0.818 (95% CI, 0.598-1.120). In the retrospective comparison of dyslipidemia risk in 170 patients and 277,864 controls, the odds ratio was 0.822 (95% CI, 0.534-1.266).ConclusionsDyslipidemia risk was not significantly different between patients with TC and the general population, in both prospective and retrospective analyses.https://www.frontiersin.org/articles/10.3389/fendo.2022.893461/fullthyroidthyroid cancerdyslipidemiahypercholesterolemialipids |
| spellingShingle | Youhyun Song Hye Sun Lee Goeun Park Sang-Wook Kang Ji Won Lee Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study Frontiers in Endocrinology thyroid thyroid cancer dyslipidemia hypercholesterolemia lipids |
| title | Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study |
| title_full | Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study |
| title_fullStr | Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study |
| title_short | Dyslipidemia Risk in Thyroid Cancer Patients: A Nationwide Population-Based Cohort Study |
| title_sort | dyslipidemia risk in thyroid cancer patients a nationwide population based cohort study |
| topic | thyroid thyroid cancer dyslipidemia hypercholesterolemia lipids |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.893461/full |
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