Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection
The paper presents data on the study of the antagonistic effect of aerococcus autosymbionts in experimental models of infections caused by staphylococci. To study the antagonistic action of aerococcus autosymbiont on staphylococcus, a model of chronic staphylococcal infection in white mice and rabbi...
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2017-06-01
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| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | http://medpers.dsma.dp.ua/issues/2017/N2/78-85.pdf |
| _version_ | 1818886980899962880 |
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| author | Stepanskyi D.O. Kremenchutskyi G.M. Koshova I.P. |
| author_facet | Stepanskyi D.O. Kremenchutskyi G.M. Koshova I.P. |
| author_sort | Stepanskyi D.O. |
| collection | DOAJ |
| description | The paper presents data on the study of the antagonistic effect of aerococcus autosymbionts in experimental models of infections caused by staphylococci. To study the antagonistic action of aerococcus autosymbiont on staphylococcus, a model of chronic staphylococcal infection in white mice and rabbits was used. In staphylococcal experimental infection, aerococcus antagonistic action against staphylococcus was tested by subcutaneous injection on white mice. Aerococci survival under the skin was studied. Aerococcus autosymbionts introduced under the skin to staphylococcus in 5 hours and 3 hours after administration of the latter cause antagonist effect and inhibit the development of infiltrates. Similar results were obtained when introducing aerococcus autosymbionts in the focus of infection in 5 minutes, 5 minutes and 3 hours, 1 and 5 hours after infection. Aerococci introduced after 24 and 48 hours shortened terms of disease manifestations as compared to the control group of mice. The therapeutic effect of aerococcus autosymbionts was tested on the experimental model of burns and wounds infected with staphylococcus. In animals with wounds treated with aerococcus autostrains the number of pathogenic staphylococci was 10 times less than in the control group. According to our observations aerococcus autosymbionts showed no irritant effect when applied on the wound surface, helped its healing, sharply reduced the percentage of staphylococcus inoculation from wound secretions. |
| first_indexed | 2024-12-19T16:29:58Z |
| format | Article |
| id | doaj.art-42c1a45eac014629a33b54547b4e78c0 |
| institution | Directory Open Access Journal |
| issn | 2307-0404 2307-0404 |
| language | English |
| last_indexed | 2024-12-19T16:29:58Z |
| publishDate | 2017-06-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj.art-42c1a45eac014629a33b54547b4e78c02022-12-21T20:14:13ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042017-06-012227885Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infectionStepanskyi D.O.0Kremenchutskyi G.M.1Koshova I.P. 2SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»The paper presents data on the study of the antagonistic effect of aerococcus autosymbionts in experimental models of infections caused by staphylococci. To study the antagonistic action of aerococcus autosymbiont on staphylococcus, a model of chronic staphylococcal infection in white mice and rabbits was used. In staphylococcal experimental infection, aerococcus antagonistic action against staphylococcus was tested by subcutaneous injection on white mice. Aerococci survival under the skin was studied. Aerococcus autosymbionts introduced under the skin to staphylococcus in 5 hours and 3 hours after administration of the latter cause antagonist effect and inhibit the development of infiltrates. Similar results were obtained when introducing aerococcus autosymbionts in the focus of infection in 5 minutes, 5 minutes and 3 hours, 1 and 5 hours after infection. Aerococci introduced after 24 and 48 hours shortened terms of disease manifestations as compared to the control group of mice. The therapeutic effect of aerococcus autosymbionts was tested on the experimental model of burns and wounds infected with staphylococcus. In animals with wounds treated with aerococcus autostrains the number of pathogenic staphylococci was 10 times less than in the control group. According to our observations aerococcus autosymbionts showed no irritant effect when applied on the wound surface, helped its healing, sharply reduced the percentage of staphylococcus inoculation from wound secretions.http://medpers.dsma.dp.ua/issues/2017/N2/78-85.pdfaerococcusantagonistic actionmodel of staphylococcus infection |
| spellingShingle | Stepanskyi D.O. Kremenchutskyi G.M. Koshova I.P. Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection Medičnì Perspektivi aerococcus antagonistic action model of staphylococcus infection |
| title | Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection |
| title_full | Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection |
| title_fullStr | Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection |
| title_full_unstemmed | Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection |
| title_short | Study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection |
| title_sort | study of action of biological aerococcus аutosymbiont on the model of staphylococcal infection |
| topic | aerococcus antagonistic action model of staphylococcus infection |
| url | http://medpers.dsma.dp.ua/issues/2017/N2/78-85.pdf |
| work_keys_str_mv | AT stepanskyido studyofactionofbiologicalaerococcusautosymbiontonthemodelofstaphylococcalinfection AT kremenchutskyigm studyofactionofbiologicalaerococcusautosymbiontonthemodelofstaphylococcalinfection AT koshovaip studyofactionofbiologicalaerococcusautosymbiontonthemodelofstaphylococcalinfection |